EDECRIN TABLET

국가: 캐나다

언어: 영어

출처: Health Canada

유효 성분:

ETHACRYNIC ACID

제공처:

BAUSCH HEALTH, CANADA INC.

ATC 코드:

C03CC01

INN (International Name):

ETACRYNIC ACID

복용량:

25MG

약제 형태:

TABLET

구성:

ETHACRYNIC ACID 25MG

관리 경로:

ORAL

패키지 단위:

100

처방전 유형:

Prescription

치료 영역:

LOOP DIURETICS

제품 요약:

Active ingredient group (AIG) number: 0101703002; AHFS:

승인 상태:

APPROVED

승인 날짜:

2004-10-07

제품 특성 요약

PRODUCT MONOGRAPH
PR
EDECRIN
®
Ethacrynic acid tablets, USP
25 mg
PR
SODIUM EDECRIN
®
Ethacrynate sodium for injection, USP
Lyophilized powder for injection, 50 mg equivalent to ethacrynic acid,
intravenous
SALURETIC-DIURETIC AGENT
BAUSCH HEALTH, CANADA INC
2150 St-Elzear Blvd. West
Laval, Quebec
H7L 4A8
Control #: 246160
EDECRIN
®
is a registered trademark of Bausch Health Companies Inc. or its
affiliates.
December
22, 2020
DATE OF
REVISION:
_Pr_
_EDECRIN & SODIUM EDECRIN_
_®_
_ Product Monograph Page 2 of 15_
PRODUCT MONOGRAPH
PR
EDECRIN
®
Ethacrynic acid tablets, USP
25 mg
PR
SODIUM EDECRIN
®
Ethacrynate sodium for injection, USP
Lyophilized powder for injection, 50 mg equivalent to ethacrynic acid,
intravenous
ACTION AND CLINICAL PHARMACOLOGY
EDECRIN (ethacrynic acid) is a saluretic-diuretic agent with marked
potency and rapid onset of
action. It is chemically unrelated to other diuretics. Patients with
congestive heart failure
(including acute pulmonary edema), renal edema, hepatic cirrhosis with
ascites, and other
conditions involving fluid retention have responded well to ethacrynic
acid.
EDECRIN has the following major characteristics:
(1)
WATER AND ELECTROLYTE EXCRETION
may be increased several times over that observed with
thiazide diuretics. The urinary output is usually dose-dependent and
related to the magnitude of
fluid accumulation.
2)
ELECTROLYTE EXCRETION PATTERN DIFFERS FROM THAT OF THIAZIDES.
Initially, sodium and chloride
excretion is usually substantial, and chloride loss exceeds that of
sodium. With prolonged
therapy, chloride excretion declines, and potassium and hydrogen ion
excretion may increase.
In patients with increased diuresis excessive amounts of potassium may
be excreted. Ethacrynic
acid is effective whether or not there is clinical acidosis or
alkalosis.
(3)
RAPID ONSET OF ACTION
usually is observed within 30 minutes after an oral dose or within 5
minutes after an intravenous injection.
(4)
DURATION OF ACTION IS MODERATE
following oral administration (6 to 8 hours). The pea