국가: 말레이시아
언어: 영어
출처: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMOXICILLIN TRIHYDRATE; GENTAMYCIN SULPHATE
RANGE PHARMA SDN. BHD.
AMOXICILLIN TRIHYDRATE; GENTAMYCIN SULPHATE
100 ml
RANGE PHARMA SDN. BHD.
CLAMOXON SP INJECTION DESCRIPTION AND COMPOSITION CLAMOXON SP INJECTION is an off white to grayish yellow oily suspension. Each ml contains 150mg of Amoxicillin trihydrate and 40mg Gentamicin (as sulphate) as its active ingredients and 50mg Benzyl alcohol as preservative. PHARMACODYNAMICS Amoxicillin is a bactericidal antibiotic belonging to the group of penicillins. It inhibits mucopeptide synthesis, one of the rigid components of bacterial cell wall that gives mechanical stability to the bacterium, destroying bacteria in the growth phase. Gentamicin is an aminoglycoside antibiotic that acts directly on the ribosome, in which it inhibits protein biosynthesis. Gentamicin penetration in the cell increases as the permeability of the bacterial cell wall is altered by amoxicillin. This allows the use of aminoglycoside smaller quantities. Amoxicillin and gentamicin together have a broad antibacterial spectrum, including Gram positive (corynebacteria) and Gram negative bacteria (_E. coli, Pasteurella _spp. and _Salmonella _spp.). Its association improving the therapeutic properties of each of these antibiotics administered alone. PHARMACOKINETICS Amoxicillin is well absorbed after parenteral administration. 17-20% of the active substance is bound to plasma proteins. It is excreted primarily in the urine unchanged and to a lesser extent for milk and bile. Gentamicin is poorly absorbed from the gastrointestinal tract, however, it is well absorbed after parenteral administration. It is rapidly distributed reaching kidney, liver, lung, endometria and parenchyma. It has biphasic excretion, first rapid phase corresponding to the distribution of the active substance in the tissue and the second phase corresponding to the slow release of the active substance tissues to the plasma and subsequent elimination from the plasma. INDICATION Cattle: For the treatment of pneumonia caused by strains of _Pasteurella multocida_ and _Arcanobacterium pyogenes_ sensitive to amoxicillin and gentamicin. For the treatment of diarrhoea caused by 전체 문서 읽기