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CHEMMART FRUSEMIDE
_Contains the active ingredient frusemide_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about frusemide. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is
Chemmart Frusemide. It contains the
active ingredient frusemide.
Frusemide belongs to a family of
drugs called diuretics. A diuretic
helps reduce the amount of excess
fluid in the body by increasing the
amount of urine produced.
Frusemide is used to treat swelling of
the ankles, feet, legs or even the
brain or lungs. This swelling is called
oedema and can occur in some heart,
lung, liver or kidney conditions.
Frusemide may be used in some
patients with more serious kidney
problems who may have some fluid
retention.
Frusemide may also be used to lower
high blood pressure (which is also
called hypertension).
Everyone has blood pressure. This
pressure helps move your blood
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
If high blood pressure is not
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Product Information
– Australia
Chemmart Frusemide tablets
Page 1
CHEMMART FRUSEMIDE TABLETS
NAME OF THE MEDICINE
Frusemide.
Chemical Name:
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Structural Formula:
Molecular Formula:
C
12
H
11
ClN
2
O
5
S
Molecular Weight:
330.744
CAS Registry Number: 54-31-9
DESCRIPTION
Frusemide is an anthranilic acid derivative. It is a white to off-white odourless crystalline powder. It is
practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and
insoluble in dilute acids.
Frusemide tablets are intended for oral administration. Each tablet contains 20 mg or 40 mg
frusemide. In addition, each tablet contains the following inactive ingredients: lactose, maize starch,
pregelatinised maize starch, sodium starch glycollate
(type A) and magnesium stearate.
PHARMACOLOGY
PHARMACODYNAMICS
Frusemide is a potent diuretic. It inhibits sodium and chloride absorption in the ascending limb of
Henle's loop and in both the proximal and distal tubules. The high degree of efficacy is due to this
unique site of action. The action on
the distal tubule is independent of any inhibitory effect on
carbonic
anhydrase or aldosterone.
Frusemide may promote diuresis in
cases which have previously proved
resistant to other diuretics.
Frusemide has no significant pharmacological effects other
than on renal function.
Pharmacokinetics
Absorption:
Frusemide is rapidly absorbed from the gastrointestinal tract. Absorption rates in healthy subjects
have been reported from 60
–69% and fro
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