CARPROVET- carprofen tablet

국가: 미국

언어: 영어

출처: NLM (National Library of Medicine)

유효 성분:

Carprofen (UNII: FFL0D546HO) (Carprofen - UNII:FFL0D546HO)

제공처:

Dechra Veterinary Products LLC

관리 경로:

ORAL

처방전 유형:

PRESCRIPTION

치료 징후:

INDICATIONS: Carprovet is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. CONTRAINDICATIONS: Carprovet should not be used in dogs exhibiting previous hypersensitivity to carprofen.

제품 요약:

HOW SUPPLIED: Carprovet is scored, and contains 25 mg, 75 mg, or 100 mg of carprofen per caplet. Each caplet size is packaged in bottles containing 30, 60, or 180 caplets.

승인 상태:

Abbreviated New Animal Drug Application

제품 특성 요약

CARPROVET- CARPROFEN TABLET
DECHRA VETERINARY PRODUCTS LLC
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CARPROVET
(CARPROFEN TABLETS)
CAPLETS
Non-steroidal anti-inflammatory drug
For oral use in dogs only
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed
veterinarian.
DESCRIPTION: Carprovet is a non-steroidal anti-inflammatory drug
(NSAID) of the
propionic acid class that includes ibuprofen, naproxen, and
ketoprofen. Carprofen is the
nonproprietary designation for a substituted carbazole,
6-chloro-α-methyl-9H-carbazole-
2-acetic acid. The empirical formula is C
H
ClNO and the molecular weight 273.72.
The chemical structure of carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically
insoluble in water at 25°C.
CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal
anti-
inflammatory agent with characteristic analgesic and antipyretic
activity approximately
equipotent to indomethacin in animal models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be
associated with the inhibition of cyclooxygenase activity. Two unique
cyclooxygenases
have been described in mammals.
The constitutive cyclooxygenase, COX-1,
synthesizes prostaglandins necessary for normal gastrointestinal and
renal function.
The inducible cyclooxygenase, COX-2, generates prostaglandins involved
in
inflammation. Inhibition of COX-1 is thought to be associated with
gastrointestinal and
renal toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity
of a particular NSAID for COX-2 versus COX-1 may vary from species to
species.
In an
_in vitro_ study using canine cell cultures, carprofen demonstrated
selective inhibition of
COX-2 versus COX-1.
Clinical relevance of these data has not been shown. Carprofen
has also been shown to inhibit the release of several prostaglandins
in two inflammatory
cell systems: rat polymorphonuclear leukocytes (PMN) and human
rheumatoid synovial
®
15
12
2
1
2
3
4
cell systems: rat polymorphonuclear leukoc