국가: 캐나다
언어: 영어
출처: Health Canada
LISINOPRIL (LISINOPRIL DIHYDRATE)
ACTAVIS PHARMA COMPANY
C09AA03
LISINOPRIL
5MG
TABLET
LISINOPRIL (LISINOPRIL DIHYDRATE) 5MG
ORAL
100/500
Prescription
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
Active ingredient group (AIG) number: 0121550003; AHFS:
CANCELLED POST MARKET
2018-06-12
_______________________________________________________________________________________________ _ACT LISINOPRIL (Lisinopril Tablets, USP) 5 mg, 10 mg and 20 mg _ _Page 1 of 43 _ _ _ _ _ PRODUCT MONOGRAPH PR ACT_ _LISINOPRIL Lisinopril Tablets, USP 5 mg, 10 mg and 20 mg (of Lisinopril as Lisinopril Dihydrate) Angiotensin Converting Enzyme Inhibitor Actavis Pharma Company 6733 Mississauga Road, Suite 400 Mississauga, Ontario Canada, L5N 6J5 Control Number: 208042 Date of Revision: September 20, 2017 _______________________________________________________________________________________________ _ACT LISINOPRIL (Lisinopril Tablets, USP) 5 mg, 10 mg and 20 mg _ _Page 2 of 43 _ _ _ _ _ _PR _ ACT_ _LISINOPRIL Lisinopril Tablets, USP 5 mg, 10 mg and 20 mg Angiotensin Converting Enzyme Inhibitor ACTIONS AND CLINICAL PHARMACOLOGY Lisinopril is an angiotensin converting enzyme (ACE) inhibitor which is used in the treatment of hypertension, congestive heart failure and following myocardial infarction in hemodynamically stable patients. ACE is a peptidyl dipeptidase which catalyzes the conversion of angiotensin I to the pressor substance, angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II, which leads to increased plasma renin activity (due to removal of negative feedback of renin release) and decreased aldosterone secretion. Although the latter decrease is small, it results in a small increase in serum potassium. In patients treated with lisinopril and a thiazide diuretic there was essentially no change in serum potassium (see PRECAUTIONS). ACE is identical to kininase II. Thus, lisinopril may also block the degradation of bradykinin, a potent vasodilator peptide. However, the role that this plays in the therapeutic effects of lisinopril is unknown. While the mechanism through which lisinopril lowers blood pressure is believed to be primarily the suppression of the renin-angiotensin-aldosterone system (RAAS), lisinopril also lowers blood pressure in patients with low-renin hypertension. PHARMACODYNA 전체 문서 읽기