TRIAMTERENE AND HYDROCHLOROTHIAZIDE tablet

Nazione: Stati Uniti

Lingua: inglese

Fonte: NLM (National Library of Medicine)

Principio attivo:

TRIAMTERENE (UNII: WS821Z52LQ) (TRIAMTERENE - UNII:WS821Z52LQ)

Commercializzato da:

St Marys Medical Park Pharmacy

INN (Nome Internazionale):

TRIAMTERENE

Composizione:

TRIAMTERENE 37.5 mg

Tipo di ricetta:

PRESCRIPTION DRUG

Stato dell'autorizzazione:

Abbreviated New Drug Application

Scheda tecnica

TRIAMTERENE AND HYDROCHLOROTHIAZIDE - TRIAMTERENE AND
HYDROCHLOROTHIAZIDE TABLET
ST MARYS MEDICAL PARK PHARMACY
----------
TRIAMTERENE AND HYDROCHLOROTHIAZIDE
TABLETS USP
REVISED: APRIL 2012
RX ONLY
DESCRIPTION:
Triamterene and hydrochlorothiazide tablets USP, combines triamterene,
a potassium-conserving
diuretic, with the natriuretic agent, hydrochlorothiazide. Triamterene
and hydrochlorothiazide tablets
are available in two strengths. Each triamterene and
hydrochlorothiazide tablet, 75 mg/50 mg, contains
triamterene USP, 75 mg and hydrochlorothiazide USP, 50 mg. Each
triamterene and hydrochlorothazide
tablet, 37.5 mg/25 mg, contains triamterene USP, 37.5 mg and
hydrochlorothiazide USP, 25 mg.
Both strengths of triamterene and hydrochlorothiazide tablets for oral
administration contain the
following inactive ingredients: anhydrous lactose, microcrystalline
cellulose, polacrilin potassium,
polyethylene glycol 8000, povidone, and magnesium stearate.
Triamterene and hydrochlorothiazide
tablets, 37.5 mg/25 mg also contain FD&C Blue #2.
Triamterene is 2, 4, 7-triamino-6-phenylpteridine. Triamterene is
practically insoluble in water,
benzene, chloroform, ether and dilute alkali hydroxides. It is soluble
in formic acid and sparingly
soluble in methoxyethanol. Triamterene is very slightly soluble in
acetic acid, alcohol and dilute
mineral acids. Its molecular weight is 253.27. Its structural formula
is:
Hydrochlorothiazide is 6-chloro-3, 4-dihydro-2_H_-1, 2,
4-benzothiadiazine-7-sulfonamide 1, 1-dioxide.
Hydrochlorothiazide is slightly soluble in water and freely soluble in
sodium hydroxide solution, n-
butylamine and dimethylformamide. It is sparingly soluble in methanol
and insoluble in ether,
chloroform and dilute mineral acids. Its molecular weight is 297.73.
Its structural formula is:
CLINICAL PHARMACOLOGY:
Triamterene and hydrochlorothiazide is a diuretic, antihypertensive
drug product, principally due to its
hydrochlorothiazide component; the triamterene component reduces the
excessive potassium loss which
may oc