TORBUTROL- butorphanol tartrate tablet

Nazione: Stati Uniti

Lingua: inglese

Fonte: NLM (National Library of Medicine)

Principio attivo:

BUTORPHANOL TARTRATE (UNII: 2L7I72RUHN) (BUTORPHANOL - UNII:QV897JC36D)

Commercializzato da:

Zoetis Inc.

INN (Nome Internazionale):

BUTORPHANOL TARTRATE

Composizione:

BUTORPHANOL TARTRATE 10 mg

Via di somministrazione:

ORAL

Tipo di ricetta:

PRESCRIPTION

Indicazioni terapeutiche:

TORBUTROL is indicated for the relief of chronic non-productive cough associated with tracheobronchitis, tracheitis, tonsillitis, laryngitis and pharyngitis originating from inflammatory conditions of the upper respiratory tract. 1. The safety of TORBUTROL has not been determined in dogs afflicted with heartworm disease (Dirofilaria immitis). 2. TORBUTROL should not be used in dogs with a history of liver disease. 3. Since TORBUTROL can be effective in totally suppressing cough, it should not be used in conditions of the lower respiratory tract      associated with copious mucus production.

Dettagli prodotto:

10 mL vials TORBUTROL (butorphanol tartrate) Veterinary Injection, 0.5 mg per mL base activity.     Bottles of 100 TORBUTROL (butorphanol tartrate)                                                                                                                                       Veterinary Tablets — 1 mg base activity (per tablet).     Bottles of 100 TORBUTROL (butorphanol tartrate)                                                                                                                                            Veterinary Tablets — 5 mg base activity (per tablet).     Bottles of 100 TORBUTROL (butorphanol tartrate)                                                                                                                                  Veterinary Tablets — 10 mg base activity (per tablet). Store at controlled room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F).

Stato dell'autorizzazione:

New Animal Drug Application

Scheda tecnica

TORBUTROL- BUTORPHANOL TARTRATE TABLET
ZOETIS INC.
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TORBUTROL
BUTORPHANOL TARTRATE
Veterinary Injection and Tablets
CIV
NADA 102-990, Approved by FDA
NADA 103-390, Approved by FDA
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
TORBUTROL (butorphanol tartrate) is a narcotic agonist-antagonist
analgesic with potent antitussive
activity. It is a member of the phenanthrene series. The chemical name
is levo-N-cyclobutylmethyl-6,
10 α, β-dihydroxy-1,2,3,9,10,10a-hexahydro-(4H)-10,
4a-iminoethanophenanthrene tartrate (1:1). It is a
white, crystalline, water soluble substance having a molecular weight
of 477.56, and its molecular
formula is C
H NO ·C H O .
CHEMICAL STRUCTURE
CLINICAL PHARMACOLOGY
In dogs, the antitussive properties of butorphanol given s.c. were
four times more potent than morphine,
10 times more potent than pentazocine (Talwin -V), and 100 times more
potent than codeine. Orally
butorphanol is approximately 15 to 20 times more active than either
codeine or dextromethorphan.
Butorphanol given intravenously in large doses (3 mg/kg) to dogs
temporarily reduced aortic blood
pressure. Aortic pressure returned to baseline control values within
15 to 30 minutes. Changes in
cardiac contractile force and cardiac rate were of the same magnitude
as the changes in aortic pressure.
No appreciable effect on expired carbon dioxide was seen.
Studies in anesthetized dogs at
equianalgetic doses indicate that butorphanol has less potential than
morphine for causing airway
constriction, hypotension and histamine release.
In conscious dogs butorphanol produced minimal
cardiovascular and respiratory effects.
The specific site of action of butorphanol is not known. Butorphanol
probably exerts analgesic and
antitussive effects via the central nervous system (subcortical,
possibly the hypothalamus).
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INDICATIONS
TORBUTROL is indicated for the relief of chronic non-productive cough
associated with
tracheobronchitis, tracheitis, tons