Nazione: Australia
Lingua: inglese
Fonte: Department of Health (Therapeutic Goods Administration)
escitalopram oxalate
Apotex Pty Ltd
escitalopram oxalate
Registered
TERRY WHITE CHEMISTS ESCITALOPRAM _Contains the active ingredient, escitalopram (as escitalopram oxalate)_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about escitalopram. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Terry White Chemists Escitalopram. It contains the active ingredient, escitalopram (as escitalopram oxalate). It is used to treat • depression • obsessive-compulsive disorder. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Escitalopram belongs to a group of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). Escitalopram and other SSRIs are thought to help by increasing the amount of serotonin in your brain. Depression is longer lasting or more severe than the "low moods" everyone has from time to time due to the stress of everyday life. It is thought to be caused by a chemical imbalance in pa Leggi il documento completo
Product Information – Australia Terry White Chemists Escitalopram Tablets Page 1 TERRY WHITE CHEMISTS ESCITALOPRAM TABLETS NAME OF THE MEDICINE Escitalopram oxalate. Chemical Name: _S_(+)-1-[3-(dimethylamino)propyl]-1-(4-flurophenyl)-1,3-dihydroisobenzofuran- 5-carbonitrile hydrogen oxalate Structural Formula: Molecular Formula: C 20 H 21 FN 2 O.C 2 H 2 O 4 Molecular Weight: 414.42 CAS Registry Number: 219861-08-2 DESCRIPTION Escitalopram is the active enantiomer (_S_-enantiomer) of citalopram. Escitalopram oxalate is a fine white to yellow, crystalline material. Escitalopram oxalate is sparingly soluble in water, slightly soluble in acetone, soluble in ethanol and freely soluble in methanol. No polymorphic forms have been detected. Each tablet contains 10 or 20 mg escitalopram (as oxalate). In addition, each tablet contains the following inactive ingredients: microcrystalline cellulose, colloidal anhydrous silica, purified talc, croscarmellose sodium, magnesium stearate, hypromellose, macrogol 400 and titanium dioxide. PHARMACOLOGY PHARMACOLOGICAL ACTIONS Biochemical and behavioural studies have shown that escitalopram is a potent inhibitor of serotonin (5-HT)-uptake (_in vitro_ IC 50 2 nM). The antidepressant action of escitalopram is presumably linked to the potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibitory effect on the reuptake of 5-HT from the synaptic cleft. Escitalopram is a highly selective Serotonin Reuptake Inhibitor (SSRI). On the basis of _ in vitro_ studies, escitalopram had no, or minimal effect on noradrenaline (NA), dopamine (DA) and gamma aminobutyric acid (GABA) uptake. In contrast to many tricyclic antidepressants and some of the SSRIs, escitalopram has no or very low affinity for a series of receptors including 5-HT 1A , 5-HT 2 , DA D 1 and DA D 2 receptors, 1 -, 2 -, β-adrenoceptors, histamine H 1 , muscarine cholinergic, benzodiazepine and opioid receptors. A series of functional _in vitro_ tests in isolated organs as well as Leggi il documento completo