Nazione: Sudafrica
Lingua: inglese
Fonte: South African Health Products Regulatory Authority (SAHPRA)
Smith_kb
TAGAMET Tablets 200 mg TAGAMET Tablets 400 mg TAGAMET Tablets 800 mg TAGAMET Syrup 200 mg/5 mL TAGAMET Ampoules 200 mg TAGAMET *I.V. 400 (Premix Intravenous solution in **‘VIAFLEX’Plastic Container) SCHEDULING STATUS: S4 PROPRIETARY NAMES (and dosage form): TAGAMET Tablets 200 mg TAGAMET Tablets 400 mg TAGAMET Tablets 800 mg TAGAMET Syrup 200 mg/5 mL TAGAMET Ampoules 200 mg TAGAMET *I.V. 400 (Premix Intravenous solution in **‘VIAFLEX’Plastic Container) COMPOSITION: The chemical name of cimetidine is: N"-Cyano-N-methyl-N'-[2[(5-melhyl-1H-imidazol-4-yl)methyl]-thio]-ethyl]guanidine. Each TAGAMET pale green round tablet contains 200 mg cimetidine . Each TAGAMET pale green oblong-shaped tablet contains 400 mg cimetidine. Each TAGAMET pale green elliptical-shaped tablet contains 800 mg cimetidine. 5 mL TAGAMET syrup contains 200 mg cimetidine as the hydrochloride. Preserved with methyl p-hydroxybenzoate 0,10% m/v and propyl p-hydroxybenzoate 0,02% m/v. Contains ethyl alcohol 2,9% v/v. Each TAGAMET ampoule contains 200 mg cimetidine in 2 mL solution. Each TAGAMET premix i/v solution in ‘VIAFLEX’plastic container contains 400 mg cimetidine in 100 mL 0,9% m/v sodium chloride. PHARMACOLOGICAL CLASSIFICATION: A 11 4 3 Antacids : Other PHARMACOLOGICAL ACTION: TAGAMET inhibits both the stimulated and basal secretion of gastric acid and reduces pepsin output. It competitively inhibits the action of histamine at the histamine H2-receptor and is thus a histamine H2-receptor antagonist. Studies have shown the degree of inhibition of basal acid secretion to vary between 80 and 100% and of stimulated acid secretion between 56 and 98% with a duration of up to 5 hours, depending on the dosage and the type of stimulation. Pharmacokinetics TAGAMET is rapidly absorbed after oral administration. The Leggi il documento completo