NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE INJECTION SOLUTION

Nazione: Canada

Lingua: inglese

Fonte: Health Canada

Principio attivo:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE)

Commercializzato da:

BAXTER CORPORATION

Codice ATC:

C01CA03

INN (Nome Internazionale):

NOREPINEPHRINE

Dosaggio:

0.016MG

Forma farmaceutica:

SOLUTION

Composizione:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE) 0.016MG

Via di somministrazione:

INTRAVENOUS

Confezione:

15G/50G

Tipo di ricetta:

Ethical

Area terapeutica:

ALPHA-AND BETA-ADRENERGIC AGONISTS

Dettagli prodotto:

Active ingredient group (AIG) number: 0131301002; AHFS:

Stato dell'autorizzazione:

APPROVED

Data dell'autorizzazione:

2020-07-02

Scheda tecnica

_Prescribing Information - Norepinephrine Bitartrate in 5% Dextrose
Injection _
_USP)_
_Page 1 of 13 _
PRESCRIBING INFORMATION
NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE INJECTION
0.016 mg / mL and 0.032 mg / mL norepinephrine
(as norepinephrine
bitartrate)
Sterile Solution
for Intravenous Infusion
Manufacturer Standard
SYMPATHOMIMETIC AMINE FOR USE IN HYPOTENSIVE EMERGENCIES
Baxter Corporation
Date of Revision:
June 24, 2021
Mississauga, Ontario
L5N 0C2
Control No.: 249005
Baxter and VIAFLO are Trademarks of Baxter International Inc.
_Prescribing Information - Norepinephrine Bitartrate in 5% Dextrose
Injection _
_USP)_
_Page 2 of 13 _
DESCRIPTION
Norepinephrine
(sometimes
referred to as _ l-arterenol/Levarterenol or l-norepinephrine) _is a
sympathomimetic
amine which differs from epinephrine by the absence of a methyl group
on the
nitrogen atom.
ACTIONS
Norepinephrine bitartrate functions
as a powerful
peripheral
vasoconstrictor
(alpha-adrenergic
action) and as a potent inotropic
stimulator
of the heart and dilator of coronary
arteries (beta-
adrenergic action). Both of these actions result in an increase in
systemic blood
pressure and
coronary artery blood flow. Cardiac output will vary reflexly in
response to
systemic hypertension
but is usually
increased in hypotensive
man when the blood
pressure is
raised
to an optimal
level.
In myocardial
infarction
accompanied
by
hypotension.
Norepinephrine bitartrate usually
increases aortic blood pressure, coronary artery blood flow, and
myocardial oxygenation,
thereby
helping to limit the area of myocardial ischemia and infarction.
Venous return is
increased and the
heart tends to resume a more normal rate and rhythm than in the
hypotensive
state.
In hypotension
that persists after correction of blood
volume
deficits,
norepinephrine bitartrate
helps raise the
blood pressure to an optimal level and establish a more adequate
circulation.
In _myocardial infarction, _norepinephrine bitartrate has been shown
to increase greatly the patient
survival rate.
Norepinephrine bitartr