Nazione: Nuova Zelanda
Lingua: inglese
Fonte: Medsafe (Medicines Safety Authority)
Methotrexate 10 mg/mL;
Hospira NZ Ltd
Methotrexate 10 mg/mL
20 mg/2mL
Solution for injection
Active: Methotrexate 10 mg/mL Excipient: Sodium chloride Sodium hydroxide Water for injection
Vial, glass, 5 x 2 mL, 10 mL
Prescription
Prescription
Fermion Oy
Package - Contents - Shelf Life: Vial, glass, 2 mL - 5 dose units - 30 months from date of manufacture stored at or below 25°C protect from light
1982-07-29
Data Sheet – New Zealand Hosp 2.0 1 DBL ® METHOTREXATE INJECTION AND TABLETS NAME OF MEDICINE Methotrexate BP PRESENTATION DBL ® Methotrexate Injection is a sterile solution of Methotrexate BP in Water for Injections BP. Sodium chloride is included for isotonicity except in the 1 g/10 mL vial. DBL ® Methotrexate Injection is preservative- free. DBL ® Methotrexate Injection has a pH of 7.5 to 9.0. DBL ® Methotrexate Tablets contain 2.5 mg of Methotrexate BP. The 2.5 mg tablets are unscored. USES _ACTIONS _ Methotrexate is an antimetabolite and an analogue of folic acid. It enters the cells via an active transport system for reduced folates and, due to a relatively irreversible binding, exerts its cytotoxic effect by competitively inhibiting the enzyme dihydrofolate reductase which catalyses the conversion of folic acid to tetrahydrofolate. This interferes with the synthesis of thymidylic acid and purines which in turn inhibits DNA synthesis and cell reproduction and to a lesser extent protein and RNA synthesis. The affinity of dihydrofolate reductase for methotrexate is far greater than its affinity for folic or dihydrofolic acid and, therefore, even very large amounts of folic acid given simultaneously will not reverse the effects of methotrexate. Methotrexate seems also to cause an increase in intracellular deoxyadenosine triphosphate, which is thought to inhibit ribonucleotide reduction and polynucleotide ligase, an enzyme concerned in DNA synthesis and repair. Methotrexate acts specifically on the S-phase of the cell cycle. Tissues with a high cellular proliferation rate such as neoplastic tissue, bone marrow, epithelial cells or foetal cells seem to be the most susceptible. Methotrexate is used for this reason in the treatment of psoriasis, where the Leggi il documento completo