LISINOPRIL TABLET

Nazione: Canada

Lingua: inglese

Fonte: Health Canada

Principio attivo:

LISINOPRIL

Commercializzato da:

SIVEM PHARMACEUTICALS ULC

Codice ATC:

C09AA03

INN (Nome Internazionale):

LISINOPRIL

Dosaggio:

40MG

Forma farmaceutica:

TABLET

Composizione:

LISINOPRIL 40MG

Via di somministrazione:

ORAL

Confezione:

100

Tipo di ricetta:

Prescription

Area terapeutica:

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

Dettagli prodotto:

Active ingredient group (AIG) number: 0121550004; AHFS:

Stato dell'autorizzazione:

CANCELLED PRE MARKET

Data dell'autorizzazione:

2022-05-27

Scheda tecnica

_LISINOPRIL Product Monograph Page 1 of 41 _
1
PRODUCT MONOGRAPH
PR
LISINOPRIL
(lisinopril tablets USP)
Tablets 5 mg, 10 mg, 20 mg and 40 mg
ANGIOTENSIN CONVERTING ENZYME INHIBITOR
Sivem Pharmaceuticals ULC
4705 Dobrin Street
Saint-Laurent, Quebec
H4R 2P7
Date of Revision:
February 1, 2018
www.sivem.ca Control No.: 212867
_ _
_LISINOPRIL Product Monograph Page 2 of 41 _
PRODUCT MONOGRAPH
PR
LISINOPRIL
(lisinopril tablets USP)
Tablets 5 mg, 10 mg, 20 mg and 40 mg
Angiotensin Converting Enzyme Inhibitor
ACTIONS AND CLINICAL PHARMACOLOGY
Lisinopril is an angiotensin converting enzyme (ACE) inhibitor which
is used in the treatment of
hypertension, congestive heart failure and following myocardial
infarction in hemodynamically
stable patients.
ACE is a peptidyl dipeptidase which catalyzes the conversion of
angiotensin I to the pressor
substance, angiotensin II. Inhibition of ACE results in decreased
plasma angiotensin II, which
leads to increased plasma renin activity (due to removal of negative
feedback of renin release)
and decreased aldosterone secretion. Although the latter decrease is
small, it results in a small
increase in serum potassium. In patients treated with lisinopril and a
thiazide diuretic there was
essentially no change in serum potassium (see PRECAUTIONS).
ACE is identical to kininase II. Thus, lisinopril may also block the
degradation of bradykinin, a
potent vasodilator peptide. However, the role that this plays in the
therapeutic effects of lisinopril
is unknown.
While the mechanism through which lisinopril lowers blood pressure is
believed to be primarily
the suppression of the renin-angiotensin-aldosterone system (RAAS),
lisinopril also lowers blood
pressure in patients with low-renin hypertension.
PHARMACODYNAMICS
Hypertension
_Adults:_ Administration of lisinopril to patients with hypertension
results in a reduction of both
supine and standing blood pressure. Abrupt withdrawal of lisinopril
has not been associated with
a rapid increase in blood pressure. In most patients studied, after
oral adm