Nazione: Stati Uniti
Lingua: inglese
Fonte: NLM (National Library of Medicine)
Dexmedetomidine Hydrochloride (UNII: 1018WH7F9I) (Dexmedetomidine - UNII:67VB76HONO)
Akorn.
INTRAMUSCULAR
PRESCRIPTION
Dexmedetomidine Hydrochloride Injection is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedetomidine Hydrochloride Injection is also indicated for use as a preanesthetic to general anesthesia in dogs and cats. Do not use Dexmedetomidine Hydrochloride Injection in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. As with all alpha2 -adrenoceptor agonists, the potential for isolated cases of hypersensitivity, including paradoxical response (excitation), exists.
Dexmedetomidine Hydrochloride Injection is supplied in 10 mL, multi-dose vials containing 0.5 mg of dexmedetomidine hydrochloride per mL.
Abbreviated New Animal Drug Application
DEXMEDETOMIDINE HYDROCHLORIDE- DEXMEDETOMIDINE HYDROCHLORIDE INJECTION, SOLUTION AKORN ANIMAL HEALTH, INC. ---------- DEXMEDETOMIDINE HYDROCHLORIDE INJECTION 0.5 MG/ML Intramuscular and Intravenous use in Dogs Intramuscular use in Cats Sedative, Analgesic, Preanesthetic CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Dexmedetomidine Hydrochloride Injection is a synthetic alpha -adrenoceptor agonist with sedative and analgesic properties. The chemical name is (+)-4-[1-(2,3- dimethylphenyl)ethyl]-1H-imidazole monohydrochloride. It is a white, or almost white, crystalline, water soluble substance having a molecular weight of 236.7. The molecular formula is C H N •HCl and the structural formula is: Each mL of Dexmedetomidine Hydrochloride Injection contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben, 0.2 mg propylparaben, 9.0 mg sodium chloride, water for injection, q.s. INDICATIONS: Dexmedetomidine Hydrochloride Injection is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedetomidine Hydrochloride Injection is also indicated for use as a preanesthetic to general anesthesia in dogs and cats. DOSAGE AND ADMINISTRATION: _DOGS: SEDATION AND ANALGESIA: 500 MCG/M_ INTRAMUSCULARLY (IM) OR 375 MCG/M INTRAVENOUSLY (IV). PREANESTHESIA: 125 OR 375 MCG/M IM. The choice of preanesthetic dose depends on the duration and severity of the procedure, as well as the anesthetic regime. The following two tables may be used to 2 13 16 2 2 2 2 determine the correct dexmedetomidine dosage. NOTE THAT THE MCG/KG DOSAGE DECREASES AS BODY WEIGHT INCREASES. For example, dogs weighing 2 kg are dosed at 28.1 mcg/kg dexmedetomidine IV, compared to dogs weighing 80 kg that are dosed at 8.7 mcg/kg. Due to the small volume of administration, accurate dosing is not possible in dogs weighing less than 2 kg (4.4 lb). TABLE 1: CANINE SEDATION/ANAL Leggi il documento completo