Nazione: Stati Uniti
Lingua: inglese
Fonte: NLM (National Library of Medicine)
Cloxacillin Sodium (UNII: 65LCB00B4Y) (Cloxacillin - UNII:O6X5QGC2VB)
Merck Sharp & Dohme Corp.
Cloxacillin Sodium
Cloxacillin 200 mg in 10 mL
INTRAMAMMARY
PRESCRIPTION
INDICATIONS: Dariclox is indicated in the treatment of bovine mastitis in lactating cows due to Streptococcus agalactiae and nonpenicillinase-producing Staphylococcus aureus . Clinical experience indicates that antibiotic efficacy in the treatment of mastitis in lactating cows is directly related to the duration of infection. Therefore, treatment should be instituted as early as possible after detection.
HOW SUPPLIED: Dariclox is supplied in cartons of 12 single-dose syringes with 12 alcohol swabs. Each 10-mL, disposable syringe contains cloxacillin sodium equivalent to 200 mg of cloxacillin. Do Not Store Above 24°C (75°F)
New Animal Drug Application
DARICLOX- CLOXACILLIN SODIUM SUSPENSION MERCK SHARP & DOHME CORP. ---------- DARICLOX (CLOXACILLIN SODIUM INTRAMAMMARY INFUSION) 191399 R1 LACTATING COW FORMULA (FÓRMULA PARA VACAS LACTANTES) INTRAMAMMARY INFUSION (INFUSIÓN INTRAMAMARIA) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Dariclox (cloxacillin sodium intramammary infusion) is a stable, nonirritating suspension of cloxacillin sodium containing the equivalent of 200 mg of cloxacillin in saturated vegetable oils per disposable syringe. Dariclox is manufactured by a nonsterilizing process. Cloxacillin is a semisynthetic penicillin derived from the penicillin nucleus, 6-amino- penicillanic acid. Cloxacillin sodium is the monohydrate sodium salt of 5-methyl-3-(o- chlorophenyl)-4-isoxazolyl penicillin. ACTION: Cloxacillin sodium is bactericidal in action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide. It is active against most gram-positive organisms associated with mastitis. It is effective against _Streptococcus agalactiae_ and nonpenicillinase-producing _Staphylococcus aureus_, and there is laboratory evidence that indicates cloxacillin is resistant to destruction by penicillinase-producing organisms. Milk cultures and antibiotic susceptibility testing is recommended when using this product. SUSCEPTIBILITY TEST: The Kirby-Bauer procedure, utilizing antibiotic susceptibility disks, is a quantitative method that may be adapted to determining the sensitivity of bacteria in milk to Dariclox. For testing the effectiveness of Dariclox in milk, follow the Kirby-Bauer procedure using the 1 mcg oxacillin susceptibility disk. Zone diameters for interpreting susceptibility are: RESISTANT INTERMEDIATE SUSCEPTIBLE ≤ 10 mm 11–12 mm ≥ 13 mm 1 INDICATIONS: Dariclox is indicated in the treatment of bovine mastitis in lactating cows due to _Streptococcus agalactiae_ and nonpenicillinase-producing _Staphylococ Leggi il documento completo