Country: Singapúr
Tungumál: enska
Heimild: HSA (Health Sciences Authority)
CILASTATIN SODIUM EQV CILASTATIN; IMIPENEM
MSD PHARMA (SINGAPORE) PTE. LTD.
J01DH51
500 mg/vial
INJECTION, POWDER, FOR SOLUTION
CILASTATIN SODIUM EQV CILASTATIN 500 mg/vial; IMIPENEM 500 mg/vial
INTRAVENOUS
Prescription Only
MERCK SHARP & DOHME CORP.
ACTIVE
1988-05-03
SG-TEN-IV-102014 ____________________ *Registered trademark of MERCK & CO., Inc., Whitehouse Station, New Jersey, USA PHYSICIANS CIRCULAR I.V. Infusion Trademark TIENAM (imipenem and cilastatin sodium, MSD) WORLDWIDE PRODUCT LABELING MRL TIENAM* (imipenem and cilastatin sodium, MSD) is a broad spectrum beta -lactam antibiotic supplied as an intravenous infusion only formulation. TIENAM consists of two components: (1) imipenem, the first of a new class of beta-lactam antibiotics, the thienamycins; and (2) cilastatin sodium, a specific enzyme inhibitor that blocks the metabolism of imipenem in the kidney, and substantially increases the concentration of intact imipenem in the urinary tract. Imipenem and cilastatin sodium are present in TIENAM in a 1:1 ratio by weight. The thienamycin class of antibiotics, to which imipenem belongs, is characterized by a spectrum of potent bactericidal activity broader than that provided by any other antibiotic studied. M ICROBIOLOGY TIENAM is a potent inhibitor of bacterial cell wall synthesis and is bactericidal against a broad spectrum of pathogens —gram-positive and gram-negative, aerobic and anaerobic. TIENAM shares with the newer cephalosporins and penicillins a broad spectrum of activity against gram-negative species, but is unique in retaining the high potency against gram- positive species, previously associated only with earlier narrow-spectrum beta-lactam antibiotics. The spectrum of activity of TIENAM includes _Pseudomonas aeruginosa, _ _Staphylococcus aureus,_ _ _ _Enterococcus_ _faecalis_ and _Bacteroides fragilis_, a Lestu allt skjalið
SG-MK0787B-IV-122020 PHYSICIANS CIRCULAR TIENAM® (imipenem and cilastatin sodium, MSD) I.V. Infusion TIENAM (imipenem and cilastatin sodium, MSD) is a broad-spectrum beta-lactam antibiotic supplied as an intravenous infusion only formulation. TIENAM consists of two components: (1) imipenem, the first of a new class of beta-lactam antibiotics, the thienamycins; and (2) cilastatin sodium, a specific enzyme inhibitor that blocks the metabolism of imipenem in the kidney, and substantially increases the concentration of intact imipenem in the urinary tract. Imipenem and cilastatin sodium are present in TIENAM in a 1:1 ratio by weight. The thienamycin class of antibiotics, to which imipenem belongs, is characterized by a spectrum of potent bactericidal activity broader than that provided by any other antibiotic studied. MICROBIOLOGY TIENAM is a potent inhibitor of bacterial cell-wall synthesis and is bactericidal against a broad spectrum of pathogens— gram-positive and gram-negative, aerobic and anaerobic. TIENAM shares with the newer cephalosporins and penicillins a broad spectrum of activity against gram-negative species but is unique in retaining the high potency against gram-positive species, previously associated only with earlier narrow-spectrum beta-lactam antibiotics. The spectrum of activity of TIENAM includes Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, and Bacteroides fragilis , a diverse group of problem pathogens commonly resistant to other antibiotics. TIENAM is resistant to degradation by bacterial beta-lactamases, which makes it active against a high percentage of organisms such as Pseudomonas aeruginosa, Serratia spp., and Enterobacter spp., which are inherently resistant to most beta-lactam antibiotics. The antibacterial spectrum of TIENAM is broader than that of any other antibiotic studied and includes virtually all clinically significant pathogens. Organisms against which TIENAM is usually active in vitro include: Gram-Negative Aerobes Achromobacter spp. Acinetobacter sp Lestu allt skjalið