Land: Ástralía
Tungumál: enska
Heimild: Department of Health (Therapeutic Goods Administration)
Ramipril
Amneal Pharma Australia Pty Ltd
Ramipril
_Ramipril CH – Consumer Medicine Information _ _ _ _ _ _ _ _ _ _Page 1 _ RAMIPRIL CH CAPSULES _Ramipril _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Ramipril CH. It does not contain all the available information. It does not take the place of talking to your doctor or, pharmacist All medicines have risks and benefits. Your doctor has weighed the risks of you taking Ramipril CH against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again WHAT RAMIPRIL CH IS USED FOR Ramipril CH belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. Ramipril CH is used to treat: • high blood pressure (hypertension) • some heart conditions such as heart failure after a heart attack • kidney problems in some patients Ramipril CH is also used to reduce the risk of cardiovascular problems and complications in patients aged 55 years or more with heart or blood vessel disease, or diabetes. HYPERTENSION Ramipril CH is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day and can be influenced by how busy or worried you are. You have hypertension when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure. HEART FAILURE AFTER A HEART ATTACK Ramipril CH may be used after a heart attack. A heart attack occurs when one of the major blood vessels supplying blood to your heart becomes blocked. This means that your heart muscle cannot receive the oxyg Lestu allt skjalið
_ _ _ _ _Ramipril CH capsules Product Information _ _ _ _Amneal Pharma Australia Pty Ltd _ Doc ID: 93.CH.P.3.0 Page 1 of 24 RAMIPRIL CH _ _ _(RAMIPRIL CAPSULES) _ _ _ PRODUCT INFORMATION _ _ NAME OF THE MEDICINE The name of the medicine is Ramipril CHEMICAL NAME: (2 _S_ ,3a _S_ ,6a _S_ )-1-[( _S_ )-2-[[( _S_ )-l-(ethoxycarbonyl)-3-phenylpropyl] amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid MOLECULAR FORMULA: C 23 H 32 N 2 O 5 MOLECULAR WEIGHT: 416.5 CAS REGISTRY NUMBER: _[87333-19-5] _ DESCRIPTION Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105 o C and 112 o C. Ramipril has five chiral centres. It has S-configuration in all five asymmetric carbon atoms. Ramipril-CH capsules contain meglumine, pregelatinised starch. The capsules are Capsugel Part No G41CSRR0331-ARTG 12044 (1.25 mg only); Capsugel Part No. G41CSRR0332- ARTG 12047 (2.5 mg only); Capsugel Part No. G41CSRR0333-ARTG 12048 (5 mg only) and Capsugel Part No. G41OSRR0334-ARTG 12045 (10 mg only). PHARMACOLOGY Mechanism of Action Ramipril is a prodrug which, after absorption from the gastrointestinal tract, is hydrolysed in the liver to form the active moiety, ramiprilat. Ramipril and ramiprilat inhibit angiotensin- converting enzyme _ _ _ _ _Ramipril CH capsules Product Information _ _ _ _Amneal Pharma Australia Pty Ltd _ Doc ID: 93.CH.P.3.0 Page 2 of 24 (ACE) which is identical to KININASE II. This converting enzyme (ACE) is a peptidyl dipeptidase that catalyses the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex, thus inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase in serum potassium. KININASE II is one of the enzymes responsible for Lestu allt skjalið