P.G. 600- gonadotrophin, chorionic and choriogonadotropin alfa injection, powder, lyophilized, for solution

Land: Bandaríkin

Tungumál: enska

Heimild: NLM (National Library of Medicine)

Virkt innihaldsefni:

CHORIONIC GONADOTROPIN (UNII: 20ED16GHEB) (CHORIONIC GONADOTROPIN - UNII:20ED16GHEB), CHORIOGONADOTROPIN ALFA (UNII: 6413W06WR3) (CHORIOGONADOTROPIN ALFA - UNII:6413W06WR3)

Fáanlegur frá:

Merck Sharp & Dohme Corp.

INN (Alþjóðlegt nafn):

Gonadotrophin, Chorionic

Samsetning:

Gonadotrophin, Chorionic 400 [iU] in 5 mL

Stjórnsýsluleið:

SUBCUTANEOUS

Gerð lyfseðils:

OTC

Ábendingar:

INDICATIONS FOR USE PREPUBERAL GILTS: P.G. 600 is indicated for induction of fertile estrus (heat) in healthy prepuberal (non-cycling) gilts over five and one-half months of age and weighing at least 85 kg (187 lb.). SOWS AT WEANING: P.G. 600 is indicated for induction of estrus in healthy weaned sows experiencing delayed return to estrus.

Vörulýsing:

P.G. 600 is available in: FIVE DOSE VIALS (order Code No. PG-720-5) - One vial containing white freezedried powder, and one vial containing sterile diluent. When reconstituted, the five dose vial (25 mL) of P.G. 600 contains:

Leyfisstaða:

New Animal Drug Application

Vara einkenni

P.G. 600- GONADOTROPHIN, CHORIONIC AND CHORIOGONADOTROPIN ALFA
INJECTION,
POWDER, LYOPHILIZED, FOR SOLUTION
MERCK SHARP & DOHME CORP.
----------
P.G. 600
(serum gonadotropin and chorionic gonadotropin for injection)
Approved by FDA under NADA # 140-856
FOR ANIMAL USE ONLY
DESCRIPTION
Gilts normally reach puberty (begin experiencing normal estrous cycles
and exhibiting
regular estrus or heat) at any time between six and eight months of
age, although some
gilts will not have exhibited their first estrus at ten months of age.
Age at first estrus is
influenced by several factors including breed type, season of the
year, environmental
conditions, and management practice (Hurtgen, 1986).
Sows normally exhibit estrus three to seven days after weaning their
litters; however,
some otherwise healthy sows may not exhibit estrus for 30 days or more
after weaning
(Dial and Britt, 1986). The causes of delayed return to estrus in
healthy sows are poorly
understood, but probably include season of the year (so-called
seasonal anestrus;
Hurtgen, 1979), adverse environmental conditions, such as high ambient
temperatures
(Love, 1978), and the number of previous litters, because the
condition is more
prevalent after the first litter than after later litters (Hurtgen,
1986).
P.G. 600 (serum gonadotropin and chorionic gonadotropin for
injection)is a combination
of serum gonadotropin (Pregnant Mare Serum Gonadotropin or PMSG) and
chorionic
gonadotropin (Human Chorionic Gonadotropin or HCG) for use in
prepuberal gilts (gilts
that have not yet exhibited their first estrus) and in sows at
weaning. It is supplied in
freeze-dried form with sterile diluent for reconstitution.
In gilts and sows, the action of serum gonadotropin is similar to the
action of Follicle-
Stimulating Hormone (FSH), which is produced by the animals' anterior
pituitary gland. It
stimulates the follicles of the ovaries to produce mature ova (eggs),
and it promotes the
outward signs of estrus (heat).
The action of chorionic gonadotropin in gilts and sows is similar to
th