OMS TIAMULIN 10% PREMIX POWDER

Land: Malasía

Tungumál: enska

Heimild: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Virkt innihaldsefni:

TIAMULIN HYDROGEN FUMARATE

Fáanlegur frá:

Osmosis Nutrition Sdn Bhd

INN (Alþjóðlegt nafn):

TIAMULIN HYDROGEN FUMARATE

Einingar í pakka:

20 kg

Framleitt af:

Osmosis Nutrition Sdn Bhd

Upplýsingar fylgiseðill

Not applicable

Vara einkenni

OMS TIAMULIN 10% PREMIX POWDER
COMPOSITION
Each g contains:
Tiamulin hydrogen fumarate.........100 mg
PRODUCT DESCRIPTION
OMS Tiamulin 10% Premix Powder is white or slightly yellowish powder.
PHARMACODYNAMICS
Tiamulin is a bacteriostatic semi-synthetic antibiotic belonging to
the pleuromutilin group of antibiotics
and acts at the ribosomal level to inhibit bacterial protein
synthesis.
Tiamulin has shown a in-vitro activity against a wide range of
bacteria such as _Brachyspira _
_hyodysenteriae, Brachyspira pilosicoli, Lawsonia intracellularis_ and
_Mycoplasma spp. _
Tiamulin is bacteriostatic at therapeutic concentrations and has been
shown to act at the 70S ribosome
level and the primary binding site is on the 50S subunit and possibly
a secondary site where the 50S and
30S subunits join. It appears to inhibit microbial protein production
by producing biochemical inactive
initiation complexes, which prevent elongation of the polypeptide
chain.
Mechanisms responsible for resistance development in Brachyspira spp
to the pleuromutilin class of
antibiotics are considered to be based on mutations at the ribosomal
target site. Clinically relevant
resistance to tiamulin requires combinations of mutations around the
tiamulin binding site.
Resistance to tiamulin may be associated with decreased susceptibility
to other pleuromutilins.
PHARMACOKINETICS
Pig
Tiamulin is well absorbed in the pig following oral administration and
widely distributed through the
body.
Tiamulin has been shown to concentrate in the lung, a target tissue,
and also in liver, where it is
metabolised and excreted in the bile, the remainder is excreted via
the kidney. Tiamulin which has not
been absorbed or metabolised, passes down the intestines to the colon
and concentrates there.
Chicken
Tiamulin is well absorbed in chickens after oral administration.
Tiamulin distributes widely through the body and to concentrate in the
liver and kidney (sites of
excretion) and in the lung. Excretion is mainly via the bile and
kidney.
INDICATION
Pig
For the treatmen