OM-200 20% ww Premix

Country: Malasía

Tungumál: enska

Heimild: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Virkt innihaldsefni:

OXYTETRACYCLINE DIHYDRATE

Fáanlegur frá:

Sunzen Corporation Sdn Bhd

INN (Alþjóðlegt nafn):

OXYTETRACYCLINE DIHYDRATE

Einingar í pakka:

25 kg

Framleitt af:

RANGE PHARMA SDN. BHD.

Vara einkenni

OM-200 20% W/W PREMIX
FOR ANIMAL USE ONLY
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S): 200g/kg Oxytetracycline (as
Dihydrate)
PRODUCT DESCRIPTION: OM-200 20% w/w Premix is light yellow powder
which contains oxytetracycline.
PHARMACODYNAMICS:
Oxytetracycline is a bacteriostatic antibiotic that prevents the
biosynthesis of bacterial proteins; this antibacterial action is
the result of binding to the 30S subunit of ribosomes by chelating
bonds with phosphate groups in messenger RNA. They
thus prevent fixation of transfer RNA on messenger RNA
(codon-anticodon interaction).
Oxytetracycline is a broad spectrum antibiotic. It is mainly active
against Gram-positive and Gram-negative bacteria, as well
as against mycoplasmas, chlamydia, leptospira and rickettsia.
Resistance can be natural or acquired and due to different mechanisms.
Many tetracycline resistance genes are known and
a large number of them are associated with mobile elements, whether in
the form of plasmids, transposons or integrons.
Three main mechanisms of resistance have been described: Three main
mechanisms of resistance have been described:
active antibiotic efflux, ribosomal protection and enzymatic
inactivation, with active efflux being the most important
mechanisms. There is a general cross-resistance between tetracyclines.
According to the CLSI (2008) standard, the cut-off points to classify
the sensitivity to the tetracyclines are as follows:
Diameter (mm)
MIC (µg / ml)
Interpretation
≥ 19
≤ 4
Susceptible
15 - 18
5 - 15
Intermediate
≤ 14
≥ 16
Resistant
PHARMACOKINETICS:
Tetracyclines are incompletely absorbed from the gastrointestinal
tract; absorption is decreased by the presence of soluble
salts of divalent and trivalent metals. They bind to a variable degree
to plasma proteins (approximately 25% oxytetracycline)
and are widely distributed throughout the body, registering the
highest concentrations in the kidney, liver, spleen and lung
as well as in the active areas of ossification and lower
concentrations in saliva, ocular humours and milk;