neosporin- neomycin sulfate, polymyxin B sulfate and bacitracin zinc ointment

Land: Bandaríkin

Tungumál: enska

Heimild: NLM (National Library of Medicine)

Virkt innihaldsefni:

neomycin sulfate (UNII: 057Y626693) (neomycin - UNII:I16QD7X297), polymyxin B sulfate (UNII: 19371312D4) (polymyxin B - UNII:J2VZ07J96K), bacitracin zinc (UNII: 89Y4M234ES) (bacitracin - UNII:58H6RWO52I)

Fáanlegur frá:

Burroughs Wellcome Inc.

INN (Alþjóðlegt nafn):

neomycin sulfate, polymyxin B sulfate and bacitracin zinc

Lyfjaform:

OINTMENT

Samsetning:

3.5 ug in 1 g

Stjórnsýsluleið:

OPHTHALMIC

Gerð lyfseðils:

PRESCRIPTION DRUG

Ábendingar:

NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Neosporin Ophthalmic Ointment is contraindicated in individuals who have shown hypersensitivity to any of its components.

Vörulýsing:

Tube of 1/8 oz (3.5 g) with ophthalmic tip (NDC 0081-0732-86). Caution: Federal law prohibits dispensing without a prescription. Store at 15° to 25°C (59° to 77°F). Manufactured by: Burroughs Wellcome Inc. Kirkland; Que., Canada H9H 4J4 for BURROUGHS WELLCOME CO. Research Triangle Park, NC 27709

Vara einkenni

NEOSPORIN- NEOMYCIN SULFATE, POLYMYXIN B SULFATE AND BACITRACIN ZINC
OINTMENT
BURROUGHS WELLCOME INC.
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NEOSPORIN OPHTHALMIC OINTMENT STERILE
(NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC OPHTHALMIC
OINTMENT, USP)
DES CRIPTION
NEOSPORIN OPHTHALMIC OINTMENT (neomycin and polymyxin B sulfates and
bacitracin zinc
ophthalmic ointment) is a sterile antimicrobial ointment for
ophthalmic use. Each gram contains:
neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B
sulfate equivalent to 10,000
polymyxin B units, bacitracin zinc equivalent to 400 bacitracin units,
and white petrolatum, q.s.
Neomycin sulfate is the sulfate salt of neomycin B and C, which are
produced by the growth of
_Streptomyces fradiae_ Waksman (Fam. Streptomycetaceae). It has a
potency equivalent of not less than 600
µg of neomycin standard per mg, calculated on an anhydrous basis. The
structural formulae are:
Polymyxin B sulfate is the sulfate salt of polymyxin B and B , which
are produced by the growth of
_Bacillus polymyxa_ (Prazmowski) Migula (Fam. Bacillaceae). It has a
potency of not less than 6,000
polymyxin B units per mg, calculated on an anhydrous basis. The
structural formulae are:
Bacitracin zinc is the zinc salt of bacitracin, a mixture of related
cyclic polypeptides (mainly bacitracin
A) produced by the growth of an organism of the _licheniformis_ group
of _Bacillus subtilis_ var Tracy. It has
a potency of not less than 40 bacitracin units per mg. The structural
formula is:
®
1
2
CLINICAL PHARMACOLOGY
A wide range of antibacterial action is provided by the overlapping
spectra of neomycin, polymyxin B
sulfate, and bacitracin.
Neomycin is bactericidal for many gram-positive and gram-negative
organisms. It is an aminoglycoside
antibiotic which inhibits protein synthesis by binding with ribosomal
RNA and causing misreading of
the bacterial genetic code.
Polymyxin B is bactericidal for a variety of gram-negative organisms.
It increases the permeability of
the bacterial cell membrane by interacting with the phosp