HYDROCHLOROTHIAZIDE tablet

Land: Bandaríkin

Tungumál: enska

Heimild: NLM (National Library of Medicine)

Virkt innihaldsefni:

HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

Fáanlegur frá:

ReadyMeds

INN (Alþjóðlegt nafn):

HYDROCHLOROTHIAZIDE

Samsetning:

HYDROCHLOROTHIAZIDE 25 mg

Stjórnsýsluleið:

ORAL

Gerð lyfseðils:

PRESCRIPTION DRUG

Ábendingar:

Hydrochlorothiazide tablets are indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Hydrochlorothiazide has also been found useful in edema due to various forms of renal dysfunction such as the nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Hydrochlorothiazide is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia. Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologi

Vörulýsing:

Hydrochlorothiazide Tablets, USP are supplied as follows: 25 mg - round scored peach colored tablet, debossed with S above score and 820 below score on one side, other side blank. NDC 67253-820-09 - Bottle of 90NDC 67253-820-10 - Bottle of 100NDC 67253-820-11 - Bottle of 1000NDC 67253-820-55 - Bottle of 5000 50 mg - round scored peach colored tablet, debossed S above score and 821 below score on one side, other side blank. NDC 67253-821-09 - Bottle of 90NDC 67253-821-10 - Bottle of 100NDC 67253-821-11 - Bottle of 1000NDC 67253-821-55 - Bottle of 5000 Store at: 20-25°C (68-77°F). [See USP]. Dispense in a well-closed container. Manufactured by: West-ward Pharmaceutical Corp Eatontown, NJ 07724, USA For: DAVA Pharmaceuticals, Inc. Fort Lee, NJ 07024, USA ReadyMeds Dothan, AL 36301 Revised: July 2007

Leyfisstaða:

Abbreviated New Drug Application

Vara einkenni

HYDROCHLOROTHIAZIDE- HYDROCHLOROTHIAZIDE TABLET
READYMEDS
----------
HYDROCHLOROTHIAZIDE
TABLETS, USP
RX ONLY
DESCRIPTION
Hydrochlorothiazide is a diuretic and antihypertensive. It is the
3,4-dihydro derivative of
chlorothiazide. Its chemical name is
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide, and its structural formula is:
Hydrochlorothiazide is a white, or practically white, crystalline
powder, which is slightly soluble in
water, but freely soluble in sodium hydroxide solution.
Each tablet, for oral administration, contains 25 mg or 50 mg
hydrochlorothiazide. In addition, each
tablet contains the
following inactive ingredients: Anhydrous Lactose, Pregelatinized
Starch from
Corn, Magnesium Stearate, Microcrystalline Cellulose, and FD&C Yellow
#6.
CLINICAL PHARMACOLOGY
The mechanism of the antihypertensive effect of thiazides is unknown.
Hydrochlorothiazide does not
usually affect normal blood pressure.
Hydrochlorothiazide affects the distal renal tubular mechanism of
electrolyte reabsorption. At maximal
therapeutic dosage all thiazides are approximately equal in their
diuretic efficacy.
Hydrochlorothiazide increases excretion of sodium and chloride in
approximately equivalent amounts.
Natriuresis may be accompanied by some loss of potassium and
bicarbonate.
After oral use diuresis begins within 2 hours, peaks in about 4 hours
and lasts about 6 to 12 hours.
PHARMACOKINETICS AND METABOLISM
Hydrochlorothiazide is not metabolized but is eliminated rapidly by
the kidney. When plasma levels
have been followed for at least 24 hours, the plasma half-life has
been observed to vary between 5.6
and 14.8 hours. At least 61 percent of the oral dose is eliminated
unchanged within 24 hours.
Hydrochlorothiazide crosses the placental but not the blood-brain
barrier and is excreted in breast milk
INDICATIONS AND USAGE
Hydrochlorothiazide tablets are indicated as adjunctive therapy in
edema associated with congestive
heart failure, hepatic cirrhosis, and corticosteroid and estrogen
therapy.
Hydrochl