HYDROCHLOROTHIAZIDE- hydrochlorothiazide tablet

Country: Bandaríkin

Tungumál: enska

Heimild: NLM (National Library of Medicine)

Virkt innihaldsefni:

HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

Fáanlegur frá:

West-ward Pharmaceutical Corp

INN (Alþjóðlegt nafn):

HYDROCHLOROTHIAZIDE

Samsetning:

HYDROCHLOROTHIAZIDE 25 mg

Stjórnsýsluleið:

ORAL

Gerð lyfseðils:

PRESCRIPTION DRUG

Ábendingar:

Hydrochlorothiazide, USP is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Hydrochlorothiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Hydrochlorothiazide is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia. Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes

Vörulýsing:

Hydrochlorothiazide Tablets, USP 25 mg: Peach, Round Tablets; Debossed "West-ward 256" on one side and Scored on the other side.     Bottles of 100 tablets.     Bottles of 1000 tablets.     Bottlets of 5000 tablets. Hydrochlorothiazide Tablets, USP 50 mg: Peach, Round Tablets; Debossed "West-ward 257" on one side and Scored on the other side.     Bottles of 100 tablets.     Bottles of 1000 tablets.     Bottles of 5000 tablets. Store at 20 - 25°C (68 - 77°F) [See USP Controlled Room Temperature]. Protect from light and moisture. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure. Manufactured By: West-ward Pharmaceutical Corp. Eatontown, NJ 07724 Revised May 2011

Leyfisstaða:

Abbreviated New Drug Application

Vara einkenni

HYDROCHLOROTHIAZIDE- HYDROCHLOROTHIAZIDE TABLET
WEST-WARD PHARMACEUTICAL CORP
----------
HYDROCHLOROTHIAZIDE TABLETS, USP
Rx Only
Rev. 05/11
DESCRIPTION
Hydrochlorothiazide, USP is a diuretic and antihypertensive. It is the
3,4-dihydro derivative of
chlorothiazide. Its chemical name is
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide and its structural formula is:
STRUCTURAL FORMULA
C H CIN O S
M.W. 297.74
Hydrochlorothiazide is a white, or practically white, crystalline
powder, which is slightly soluble in
water, but freely soluble in sodium hydroxide solution.
Each tablet for oral administration contains 25 mg or 50 mg of
hydrochlorothiazide USP. In addition,
each tablet contains the following inactive ingredients: Anhydrous
Lactose, Calcium Stearate, Corn
Starch, Dibasic Calcium Phosphate, FD&C Yellow No. 6, FD&C Yellow No.
10, and Sodium Starch
Glycolate.
CLINICAL PHARMACOLOGY
The mechanism of the antihypertensive effect of thiazides is unknown.
Hydrochlorothiazide does not
usually affect normal blood pressure.
Hydrochlorothiazide affects the distal renal tubular mechanism of
electrolyte reabsorption. At maximal
therapeutic dosage all thiazides are approximately equal in their
diuretic efcacy.
Hydrochlorothiazide increases excretion of sodium and chloride in
approximately equivalent amounts.
Natriuresis may be accompanied by some loss of potassium and
bicarbonate.
After oral use diuresis begins within 2 hours, peaks in about 4 hours
and lasts about 6 to 12 hours.
PHARMACOKINETICS AND METABOLISM
Hydrochlorothiazide is not metabolized but is eliminated rapidly by
the kidney. When plasma levels
have been followed for at least 24 hours, the plasma half-life has
been observed to vary between 5.6
and 14.8 hours. At least 61 percent of the oral dose is eliminated
unchanged within 24 hours.
Hydrochlorothiazide crosses the placental but not the blood-brain
barrier and is excreted in breast milk.
7
8
3
4
2
INDICATIONS AND USAGE
Hydrochlorothiazide, USP is indicated as adjunctive therapy in