HYDROCHLOROTHIAZIDE capsule

Land: Bandaríkin

Tungumál: enska

Heimild: NLM (National Library of Medicine)

Virkt innihaldsefni:

HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

Fáanlegur frá:

Life Line Home Care Services, Inc.

INN (Alþjóðlegt nafn):

HYDROCHLOROTHIAZIDE

Samsetning:

HYDROCHLOROTHIAZIDE 12.5 mg

Stjórnsýsluleið:

ORAL

Gerð lyfseðils:

PRESCRIPTION DRUG

Ábendingar:

Hydrochlorothiazide Capsules are indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other antihypertensives. Unlike potassium sparing combination diuretic products, Hydrochlorothiazide Capsules may be used in those patients in whom the development of hyperkalemia cannot be risked, including patients taking ACE inhibitors. Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy resulting from restriction of venous return by the expanded u

Vörulýsing:

Hydrochlorothiazide capsules 12.5 mg are available as hard gelatin capsules with opaque white cap and opaque white body imprinted with "U" on cap and "130" on the body in grey ink along the horizontal axis Bottles of 100:  NDC 29300-130-01 Bottles of 500:  NDC 29300-130-05 Bottles of 1000:  NDC 29300-130-10 Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].  Protect from light, moisture, freezing, -20°C (-4°F). Keep container tightly closed. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Rx only Manufactured by:

Leyfisstaða:

Abbreviated New Drug Application

Vara einkenni

HYDROCHLOROTHIAZIDE - HYDROCHLOROTHIAZIDE CAPSULE
LIFE LINE HOME CARE SERVICES, INC.
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HYDROCHLOROTHIAZIDE CAPSULES
Rx Only
DESCRIPTION
Hydrochlorothiazide is the 3, 4-dihydro derivative of chlorothiazide.
Its chemical name is 6-Chloro-3,
4-dihydro -2H-1, 2, 4-benzothiadiazine-7-sulfonamide-1, 1-dioxide. Its
empirical formula is
C H CIN O S ; its molecular weight is 297.74; and its structural
formula is:
It is a white, or practically white, crystalline powder which is
slightly soluble in water, but freely
soluble in sodium hydroxide solution.
Hydrochlorothiazide is supplied as 12.5 mg capsules for oral use.
_Inactive ingredients_: microcrystalline cellulose, pregelatinized
starch, colloidal silicon dioxide,
magnesium stearate, gelatin, titanium dioxide, sodium lauryl sulfate
and black iron oxide.
CLINICAL PHARMACOLOGY
Hydrochlorothiazide blocks the reabsorption of sodium and chloride
ions, and it thereby increases the
quantity of sodium traversing the distal tubule and the volume of
water excreted. A portion of the
additional sodium presented to the distal tubule is exchanged there
for potassium and hydrogen ions.
With continued use of hydrochlorothiazide and depletion of sodium,
compensatory mechanisms tend to
increase this exchange and may produce excessive loss of potassium,
hydrogen and chloride ions.
Hydrochlorothiazide also decreases the excretion of calcium and uric
acid, may increase the excretion
of iodide and may reduce glomerular filtration rate. Metabolic
toxicities associated with excessive
electrolyte changes caused by hydrochlorothiazide have been shown to
be dose-related.
PHARMACOKINETICS AND METABOLISM:
Hydrochlorothiazide is well absorbed (65% to 75%) following oral
administration. Absorption of
hydrochlorothiazide is reduced in patients with congestive heart
failure.
Peak plasma concentrations are observed within 1 to 5 hours of dosing,
and range from 70 to 490 ng/mL
following oral doses of 12.5 to 100 mg. Plasma concentrations are
linearly related to the administered
dose. Concentrati