Land: Malasía
Tungumál: enska
Heimild: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol
Alpharme Plc Sdn. Bhd.
Paracetamol
10 Tablets; 100 Tablets; 500 Tablets; 1000 Tablets
Farmalabor - Produtos Farmaceuticos, S.A.
COXA 500 TABLET Paracetamol 500mg 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Coxa 500 Tablet is used for 2. How Coxa 500 Tablet works 3. Before you use Coxa 500 Tablet 4. How to use Coxa 500 Tablet 5. While you are using it 6. Side effects 7. Storage and Disposal of Coxa 500 Tablet 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT COXA 500 TABLET IS USED FOR Coxa 500 tablets is used for the relief of fever and reduce pain. HOW COXA 500 TABLET WORKS Coxa Tablet contains Paracetamol which has analgesic (pain relief) and antipyretic (anti-fever) properties. BEFORE YOU USE COXA 500 TABLET - _When you must not use it _ Do not take Coxa 500 Tablet if: • You have ever had an allergic reaction to Paracetamol or to any of the other ingredients • You are taking other medicines containing paracetamol. _ _ If you are not sure whether you should take this medicine, ask your doctor or pharmacist for advice before taking any medicine. _ _ - _Before you start use it _ Tell your doctor or pharmacist if • You have liver or kidney disease. • You are pregnant or breastfeeding. Ill effects in human have not been reported when taking paracetamol during pregnancy or breastfeeding. • You are taking other medicine that affect the liver - _Taking other medicines _ Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Inform your doctor or pharmacist if you are taking if you are taking cholestyramine, metoclopramide, domperidone, warafin, chloramphenicol, non-steroidal anti-inflammatory drug (NSAIDs), alcohol, hepatic enzyme inducers, hepatotoxic medications. HOW TO USE COXA 500 TABLET - _How much to use _ • Adults and children over 12 years: 1 - 2 tablets three to four times daily as required. Not more than 8 tablets in 24 hours unless instructed by a doctor. • Children under 12 years: Not recommended. Follow all directions Lestu allt skjalið
COXA 500 TABLET NAME AND STRENGTH OF ACTIVE SUBSTANCE Coxa 500 Tablet Each tablet contains paracetamol 500mg. PRODUCT DESCRIPTION Coxa 500 tablet is a white round, uniform and scored on one side. The score line is not intended to divide the tablet into equal doses. PHARMACODYNAMIC Paracetamol has analgesic and antipyretic effects. It may produce analgesia by inhibiting prostaglandin synthesis in the central nervous system and through a peripheral action by blocking pain impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitise pain receptors to mechanical or chemical stimulation. Paracetamol probably produces antipyresis by acting centrally on the hypothalamic heat regulating centre to produce peripheral vasodilation resulting in increased blood flow through skin, sweating and heat loss. The central action probably involves the inhibition of prostaglandin synthesis in the hypothalamus. PHARMACOKINETIC Absorption The oral absorption of paracetamol is rapid and almost completely absorbed from the gastro-intestinal tract with peak plasma concentration occurring about 0.5 to 2 hours after ingestion and may be decreased if taken after a high carbohydrate meal. Distribution Paracetamol is distributed rapidly throughout all tissues. Concentrations are comparable in blood, saliva and plasma. The volume of distribution of Paracetamol is approximately 1 L/kg bodyweight. At therapeutic doses protein binding is negligible. Metabolism Protein binding is not significant with doses producing plasma concentration below 60mcg/ml but may reach moderate level with high or toxic doses. Approximately 90% - 95% of a dose is metabolized in the liver, primarily by conjugation with glucuronic acid, sulphuric acid and cysteine. An intermediate metabolite, which may accumulate in overdosage after the primary metabolic pathways become saturated, is hepatotoxic and possibly nephrotoxic. The half -life is 1-4 hours and does Lestu allt skjalið