Land: Ástralía
Tungumál: enska
Heimild: Department of Health (Therapeutic Goods Administration)
cisatracurium besilate
Pfizer Australia Pty Ltd
cisatracurium besilate
Registered
CISATRACURIUM PFIZER ® _Cisatracurium (as besylate)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about CISATRACURIUM PFIZER. It does not contain all of the available information. Reading this leaflet does not take the place of talking to your doctor or pharmacist. Taking any medicine involves some risk. It is possible that all risks associated with this medicine might not have been detected, despite proper testing. Only your doctor or pharmacist is able to weigh up all of the relevant facts, and you should consult them if you have any queries. IF YOU HAVE ANY CONCERNS ABOUT THE USE OF CISATRACURIUM PFIZER ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS INFORMATION. You may want to read it again. This leaflet provides information about CISATRACURIUM PFIZER. The statements that are made in this leaflet cannot be applied to any other medicine, even those that are similar or appear to contain the same ingredients. WHAT CISATRACURIUM PFIZER IS USED FOR CISATRACURIUM PFIZER is used to relax the body's muscles. CISATRACURIUM PFIZER will normally be given to you when you are in surgery, or during other medical procedures. Cisatracurium Pfizer is only used in conjunction with an anaesthetic, so you will be asleep during the procedure. IF YOU HAVE ANY QUESTIONS ABOUT WHY CISATRACURIUM PFIZER IS USED ASK YOUR DOCTOR. _HOW DOES CISATRACURIUM_ _PFIZER WORKS_ Cisatracurium besylate (the active ingredient in CISATRACURIUM PFIZER) belongs to a group of medicines called "neuromuscular blockers". CISATRACURIUM PFIZER works by blocking the effects of one of the body's chemical messengers called acetylcholine. Acetylcholine is involved in muscle contraction. By relaxing your body's muscles CISATRACURIUM PFIZER makes it easier for you to be kept asleep (under anaesthesia) or sedation. Your doctor will be able to provide you with more information. BEFORE YOU USE CISATRACURIUM PFIZER CISATRACURIUM PFIZER IS NOT SUITABLE FOR EVERYONE. BEFORE CISATRACURIUM PFIZER IS USED MAKE SURE THAT YOUR Lestu allt skjalið
Version: pfpcisai10713 Supersedes: pfpcisai10213 Page 1 of 16 PRODUCT INFORMATION CISATRACURIUM PFIZER CISATRACURIUM BESYLATE NAME OF THE MEDICINE The chemical name of cisatracurium besylate is (1R,1’R,2R,2’R,)-2,2’-(3,11-dioxo-4,10- dioxatridecamethylene) bis (1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1- veratrylisoquinolinium) dibenzenesulfonate. The molecular formula of cisatracurium besylate is C 65 H 82 N 2 O 18 S 2 and it has a molecular weight of 1243.5. The structural formula is given below: CAS NUMBER: 96946-42-8 DESCRIPTION Cisatracurium besylate is a white to pale yellow powder. CISATRACURIUM PFIZER is supplied in a concentration of 2.68 mg/mL cisatracurium besylate, equivalent to cisatracurium 2 mg/mL. CISATRACURIUM PFIZER also contains Water for Injections and benzenesulfonic acid. CISATRACURIUM PFIZER does not contain any preservative and is for single use in one patient only. Discard any residue. PHARMACOLOGY PHARMACODYNAMICS Cisatracurium besylate, a stereoisomer of atracurium, is an intermediate duration, non- depolarising benzylisoquinolinium skeletal muscle relaxant. Cisatracurium besylate binds to Version: pfpcisai10713 Supersedes: pfpcisai10213 Page 2 of 16 cholinergic receptors on the motor end-plate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anticholinesterase agents such as neostigmine. The ED 95 (dose required to produce 95% depression of the twitch response of the adductor pollicis muscle to stimulation of the ulnar nerve) of cisatracurium besylate is estimated to be 0.05 mg/kg bodyweight during opioid anaesthesia (thiopentone, fentanyl, midazolam). The recommended intubation dose for cisatracurium besylate in adults is 3 × ED 95 , which has a longer clinically effective duration than the recommended intubation dose of atracurium (2 × ED 95 ) (see DOSAGE AND ADMINISTRATION). The ED 95 of cisatracurium besylate in children during halothane anaesthesia is 0.04 mg/kg bodyweight. Ci Lestu allt skjalið