Land: Ástralía
Tungumál: enska
Heimild: Department of Health (Therapeutic Goods Administration)
Indapamide hemihydrate
Apotex Pty Ltd
Medicine Registered
CHEMMART INDAPAMIDE _Contains the active ingredient, indapamide hemihydrate (pronounced ind-ap-a-mide)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about indapamide. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Chemmart Indapamide. It contains the active ingredient, indapamide hemihydrate. It is used either alone or with other medicines to treat: • mild to moderate hypertension (high blood pressure). Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Indapamide, at a dose of 2.5 mg, is thought to lower blood pressure by relaxing some of the blood vessels in the body. The blood vessels can then carry the same volume of blood more easily. It is not fully understood how it exactly does this. Indapamide can be used alone or in combination with other medicines to lower blood pressure. Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depend Lestu allt skjalið
Product Information – Australia Chemmart Indapamide Tablets Page 1 CHEMMART INDAPAMIDE NAME OF THE MEDICINE Indapamide hemihydrate. Chemical Name: Indapamide hemihydrate is 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl benzamide hemihydrate. Chemical Structure: Molecular Formula: C 16 H 16 CIN 3 O 3 S, ½ H 2 O Molecular weight: 374.85. CAS Registry Number: 26807-65-8. DESCRIPTION Indapamide hemihydrate is a nonthiazide indole derivative of chlorosulfonamide. It is a white crystalline lipophilic powder, soluble in methanol, ethanol, acetic acid and ethyl acetate, very slightly soluble in ether, chloroform and benzene and practically insoluble in water. Melting point: approximately 185°C. PHARMACOLOGY PHARMACODYNAMICS Indapamide is an oral antihypertensive agent. The mechanism whereby indapamide exerts its antihypertensive action has not been completely elucidated; both vascular and renal actions have been implicated. At a dose of 2.5 mg the renal effects of indapamide are minimal and the antihypertensive effect of indapamide has been attributed to a reduction in vascular reactivity to pressor amines. The finding that indapamide retains its antihypertensive activity in functionally anephric patients lends support to the hypothesis. The renal site of action of indapamide is the proximal segment of the distal tubule. Indapamide appears to have natriuretic properties (sodium and chloride being excreted in equivalent amounts) with less effect on kaliuresis or uric acid excretion. Only at doses greater than 2.5 mg/day is an appreciable increase in urinary volume observed in humans. No significant changes in plasma sodium levels have been observed in clinical studies. Significant hypokalaemia (plasma potassium < 3.2 mmol/L has been reported Lestu allt skjalið