Land: Bandaríkin
Tungumál: enska
Heimild: NLM (National Library of Medicine)
CEFAZOLIN SODIUM (UNII: P380M0454Z) (CEFAZOLIN - UNII:IHS69L0Y4T)
APP Pharmaceuticals, LLC
CEFAZOLIN SODIUM
CEFAZOLIN 20 g in 100 mL
PRESCRIPTION DRUG
Abbreviated New Drug Application
CEFAZOLIN- CEFAZOLIN INJECTION, POWDER, FOR SOLUTION APP PHARMACEUTICALS, LLC ---------- CEFAZOLIN FOR INJECTION, USP PHARMACY BULK PACKAGE NOT FOR DIRECT INFUSION To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefazolin for Injection, USP and other antibacterial drugs, Cefazolin for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION Cefazolin for Injection, USP is a semi-synthetic cephalosporin for parenteral administration. It is the sodium salt of (6_R_,7_R_)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1_H_-tetrazol-1- yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Structural Formula: C H N NAO S M.W. 476.49 The pH of the constituted solution is between 4 and 6. Each pharmacy bulk package bottle contains 48 mg of sodium/1 gram of cefazolin sodium. Cefazolin for Injection, USP is supplied in 20 g bottles and is intended for intravenous infusion only. Each Pharmacy Bulk bottle contains cefazolin sodium equivalent to 20 g of cefazolin. A pharmacy bulk package is a container of a sterile preparation for intravenous use that contains many single doses. The contents are intended for use in a pharmacy admixture service and are restricted to the preparation of admixtures for intravenous infusion. FURTHER DILUTION IS REQUIRED BEFORE USE. CLINICAL PHARMACOLOGY Studies have shown that following intravenous administration of cefazolin to normal volunteers, mean serum concentrations peaked at approximately 185 mcg/mL and were approximately 4 mcg/mL at 8 hours for a 1 gram dose. The serum half-life for cefazolin is approximately 1.8 hours following IV administration. In a study (using normal volunteers) of constant intravenous infusion with dosages of 3.5 mg/kg for 1 hour (approximately 250 mg) and 1.5 mg/kg the next 2 hours (approximately 100 mg), cefazolin produced a steady serum level at the third hour of approximately 28 mcg/mL. Studies in patients hosp Lestu allt skjalið