APO AMPI CAPSULES 500MG

Land: Kanada

Tungumál: enska

Heimild: Health Canada

Virkt innihaldsefni:

AMPICILLIN

Fáanlegur frá:

APOTEX INC

ATC númer:

J01CA01

INN (Alþjóðlegt nafn):

AMPICILLIN

Skammtar:

500MG

Lyfjaform:

CAPSULE

Samsetning:

AMPICILLIN 500MG

Stjórnsýsluleið:

ORAL

Einingar í pakka:

100/500

Gerð lyfseðils:

Prescription

Lækningarsvæði:

AMINOPENICILLINS

Vörulýsing:

Active ingredient group (AIG) number: 0105872001; AHFS:

Leyfisstaða:

CANCELLED POST MARKET

Leyfisdagur:

2019-12-02

Vara einkenni

Page 1 of 8
PRESCRIBING INFORMATION
Including Patient Medication Information
APO-AMPI
Ampicillin Trihydrate, USP
250 and 500 mg Capsules
125 mg per 5 mL
250 mg per 5 mL
Powder for Oral Suspension
ANTIBIOTIC
APOTEX INC.
150 SIGNET DRIVE
TORONTO, ONTARIO
M9L1T9
CONTROL NO: 217173
DATE OF PREPARATION:
March 20, 2019
Page 2 of 8
PHARMACOLOGY:
Ampicillin, a semisynthetic penicillin, is similar to benzylpenicillin
in its bactericidal
action against sensitive organisms during the stage of active
multiplication. It acts through the inhibition
of biosynthesis of cell wall mucopeptide.
Ampicillin differs in vitro spectrum from benzylpenicillin in the
gram-negative spectrum. It exerts high in
vitro activity against many strains of H. influenzae, N. gonorrhoeae,
N. meningitidis, B. catarrhalis, E.
coli, P. mirabilis, B. funduliformis, Salmonellae and Shigellae.
In vitro studies have also demonstrated the sensitivity of many
strains of the following gram positive
bacteria: alpha-and beta-hemolytic streptococci, S. pneumoniae,
non-beta-lactamase (penicillinase)-
producing staphylococci, B. anthracis, and most strains of enterococci
and clostridia. Ampicillin generally
provides less in vitro activity than penicillin G against gram
positive bacteria. Because it does not resist
destruction by beta-lactamase, it is not effective against
beta-lactamase-producing bacteria, particularly
resistant staphylococci. All strains of Pseudomonas and most strains
of Klebsiella and Aerobacter are
resistant. Ampicillin is not active against Rickettsia, Mycoplasma and
'large viruses' (Chiamydia).
Ampicillin is acid stable and therefore, well absorbed. Food, however,
retards absorption. Ampicillin
diffuses readily into most body tissues and fluids; however,
penetration into the cerebrospinal fluid and
brain occurs only with meningeal inflammation. Ampicillin is excreted
largely unchanged in the urine; its
excretion can be delayed by concurrent administration of probenecid.
In blood serum, ampicillin is the
least bound of all the penicillins; an a