Alovasc Tablet 5mg

Land: Malasía

Tungumál: enska

Heimild: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Virkt innihaldsefni:

AMLODIPINE BESYLATE

Fáanlegur frá:

GoodScience Sdn. Bhd.

INN (Alþjóðlegt nafn):

AMLODIPINE BESYLATE

Einingar í pakka:

3 x 10 Tablets

Framleitt af:

XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD

Upplýsingar fylgiseðill

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
_ _
_ _
___________________________________________________________________________________________________________________________
_
______________________________________________________________________________________________________________
1
WHAT IS IN THIS LEAFLET
1.
What is Alovasc used for
2.
How Alovasc works
3.
Before you use Alovasc
4.
How to use Alovasc
5.
While you are using Alovasc
6.
Side effects
7.
Storage and Disposal of Alovasc
8.
Product description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
WHAT IS ALOVASC USED FOR
It is used to treat high blood pressure
(hypertension) and the condition where
there is a reduced blood supply of the heart
muscle (myocardial ischemia).
HOW ALOVASC WORKS
Amlodipine
belongs
to
a
group
of
medicines known as calcium antagonist. it
dilates
the
blood
vessels
by
muscle
relaxing.
Once
the
blood
vessels
are
dilated, blood is able to pass through easily
and thereby improve blood supply to the
heart muscle.
BEFORE YOU USE ALOVASC
_When you must not use it _
Do not take this medicine if you:
•
are
allergic
(hypersensitive)
to
amlodipine, dihydropyridines (a group
of medicines where calcium antagonist
belonged to) or any of the excipients in
this medicines.
•
experience cardiogenic shock (the heart
is unable to supply sufficient blood to
the body).
•
have narrowing of the aortic heart valve
(aortic stenosis).
•
have
unstable
chest
pain
(excluding
Prinzmetal’s
angina
which
occurs
at
rest,
and
often
without
a
predictable
pattern).
_Before you start to use it _
Tell your doctor or pharmacist if you have:
•
severe aortic stenosis.
•
heart failure
•
impaired liver function
•
are pregnant or plan to pregnant.
•
are breast feeding or plan to start breast
feeding.
_Taking other medicines _
Tell your doctor if you are taking any other
medicines,
including
any
that
you
buy
without a prescription from a pharmacy,
supermarket or health food shop.
HOW TO USE ALOVASC
_How much to use _
_Adults

Vara einkenni

Important information. Please read carefully.
_ALOVASC_
TABLET 5 MG / 10 MG
COMPOSITION
ALOVASC 5 MG
: Each tablet contains Amlodipine Besylate equivalent to Amlodipine 5
mg
ALOVASC 10 MG
: Each tablet contains Amlodipine Besylate equivalent to Amlodipine 10
mg
PHARMACODYNAMICS
Amlodipine is a calcium ion influx inhibitor of the dihydropyridine
group (slow channel blocker
or calcium ion antagonist) and inhibits the transmembrane influx of
calcium ions into cardiac and
vascular smooth muscle.
The mechanism of the antihypertensive action of amlodipine is due to a
direct relaxant effect on
vascular smooth muscle. The precise mechanism by which amlodipine
relieves angina has not
been fully determined but amlodipine reduces total ischaemic burden by
the following two
actions:
1.
Amlodipine dilates peripheral arterioles and thus, reduces the total
peripheral resistance
(afterload) against which the heart works. Since the heart rate
remains stable, this
unloading of the heart reduces myocardial energy consumption and
oxygen requirements.
2.
The mechanism of action of amlodipine also probably involves
dilatation of the main
coronary arteries and coronary arterioles, both in normal and
ischaemic regions. This
dilatation increases myocardial oxygen delivery in patients with
coronary artery spasm
(Prinzmetal's or variant angina).
In patients with hypertension, once daily dosing provides clinically
significant reductions of
blood pressure in both the supine and standing positions throughout
the 24 hour interval. Due to
the slow onset of action, acute hypotension is not a feature of
amlodipine administration.
In patients with angina, once daily administration of amlodipine
increases total exercise time,
time to angina onset, and time to 1mm ST segment depression, and
decreases both angina attack
frequency and nitroglycerine tablet consumption.
Amlodipine has not been associated with any adverse metabolic effects
or changes in plasma
lipids and is suitable for use in patients with asthma, diabetes, and
gout.
PHARMACOKINETICS
A