ACYCLOVIR - acyclovir capsule

Land: Bandaríkin

Tungumál: enska

Heimild: NLM (National Library of Medicine)

Virkt innihaldsefni:

Acyclovir (UNII: X4HES1O11F) (Acyclovir - UNII:X4HES1O11F)

Fáanlegur frá:

Heritage Pharmaceuticals, Inc.

INN (Alþjóðlegt nafn):

Acyclovir

Samsetning:

Acyclovir 200 mg

Stjórnsýsluleið:

ORAL

Gerð lyfseðils:

PRESCRIPTION DRUG

Ábendingar:

Herpes Zoster Infections: acyclovir is indicated for the acute treatment of herpes zoster (shingles). Genital Herpes: acyclovir is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Chickenpox: acyclovir is indicated for the treatment of chickenpox (varicella). Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

Leyfisstaða:

Abbreviated New Drug Application

Vara einkenni

ACYCLOVIR - ACYCLOVIR CAPSULE
HERITAGE PHARMACEUTICALS, INC.
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ACYCLOVIR CAPSULES
DESCRIPTION
Acyclovir is a synthetic nucleoside analogue active against
herpesviruses. Acyclovir capsules are
formulations for oral administration.
Each capsule contains 200 mg of acyclovir and the inactive
ingredients: lactose monohydrate, sodium
lauryl sulfate, sodium starch glycolate, and magnesium stearate. The
capsule shell consists of FDandC
Blue #1, FDandC Blue #2, FDandC Red #40, DandC Yellow #10, iron oxide
black, pharmaceutical
shellac glaze and propylene glycol.
Acyclovir is a white, crystalline powder with the molecular formula C
H N O and a molecular
weight of 225. The maximum solubility in water at 37degree C is 2.5
mg/mL. The pka's of acyclovir
are 2.27 and 9.25.
The chemical name of acyclovir is
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6_H_-purin-6-one;
it has the following structural formula
VIROLOGY
MECHANISM OF ANTIVIRAL ACTION: Acyclovir is a synthetic purine
nucleoside analogue with in vitro and
in vivo inhibitory activity against herpes simplex virus types 1
(HSV-1), 2 (HSV-2), and varicella-zoster
virus (VZV). The inhibitory activity of acyclovir is highly selective
due to its affinity for the enzyme
thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme
converts acyclovir into acyclovir
monophosphate, a nucleotide analogue. The monophosphate is further
converted into diphosphate by
cellular guanylate kinase and into triphosphate by a number of
cellular enzymes. In vitro, acyclovir
triphosphate stops replication of herpes viral DNA. This is
accomplished in 3 ways: 1) competitive
inhibition of viral DNA polymerase, 2) incorporation into and
termination of the growing viral DNA
chain, and 3) inactivation of the viral DNA polymerase. The greater
antiviral activity of acyclovir
against HSV compared to VZV is due to its more efficient
phosphorylation by the viral TK.
ANTIVIRAL ACTIVITIES: The quantitative relationship between the in
vitro susceptibility of herpes viruses
to antivirals and t