TEVA-TRIMEL SUSPENSION

Negara: Kanada

Bahasa: Inggris

Sumber: Health Canada

Bahan aktif:

SULFAMETHOXAZOLE; TRIMETHOPRIM

Tersedia dari:

TEVA CANADA LIMITED

Kode ATC:

J01EE01

INN (Nama Internasional):

SULFAMETHOXAZOLE AND TRIMETHOPRIM

Dosis:

40MG; 8MG

Bentuk farmasi:

SUSPENSION

Komposisi:

SULFAMETHOXAZOLE 40MG; TRIMETHOPRIM 8MG

Rute administrasi :

ORAL

Unit dalam paket:

100/400/800ML

Jenis Resep:

Prescription

Area terapi:

SULFONAMIDES

Ringkasan produk:

Active ingredient group (AIG) number: 0208901002; AHFS:

Status otorisasi:

APPROVED

Tanggal Otorisasi:

2014-02-07

Karakteristik produk

PRODUCT MONOGRAPH
Including Patient Medication Information
PR TEVA-TRIMEL TABLETS
PR TEVA-TRIMEL DS TABLETS
sulfamethoxazole and trimethoprim tablets
PR TEVA-TRIMEL ORAL SUSPENSION
sulfamethoxazole and trimethoprim oral suspension
ANTIBACTERIAL AGENT
Teva Canada Limited
DATE OF REVISION:
30 Novopharm Court
February 2, 2018
Toronto, Ontario
Canada M1B 2K9
www.tevacanada.com
Submission Control: 205917
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PRODUCT MONOGRAPH
PR TEVA-TRIMEL TABLETS AND ORAL SUSPENSION
(sulfamethoxazole and trimethoprim)
ANTIBACTERIAL AGENT
CLINICAL PHARMACOLOGY
Teva-Trimel (sulfamethoxazole and trimethoprim) is an antibacterial
agent with a wide spectrum
of activity. It contains two active antibacterial components,
sulfamethoxazole and trimethoprim,
which act synergistically on many species of bacteria.
FIGURE 1
Sulfamethoxazole and trimethoprim act sequentially in two successive
steps in the biosynthesis
of nucleic acids. Trimethoprim is an inhibitor of dihydrofolate
reductase, the enzyme which
reduces dihydrofolic acid to its tetrahydro form. This biochemical
step is essential in the
production of the folate coenzymes which are involved in the
biosynthesis of thymine, purine,
serine and methionine. Sulfamethoxazole exerts its antibacterial
activity by competing with para-
aminobenzoic acid.
Most pathogenic bacteria meet their need for dihydrofolic acid by
synthesizing it from para-
aminobenzoic acid, pteridine and glutamic acid. Animals, in contrast,
depend on exogenous
sources for their needs of folic acid and do not rely upon
intracellular synthesis.
Under usual circumstances, sulfamethoxazole or trimethoprim acting
alone do not produce
complete block in this biosynthesis of nucleic acids. Instead, they
cause sufficient reduction in
the synthesis of folate coenzymes to produce bacteriostasis. When the
two agents act together,
the superimposition of their effects produces a complete block in the
synthesis, leading to death
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of the organism. Thus the effect of the dual