TEVA-PINDOLOL TABLET

Negara: Kanada

Bahasa: Inggris

Sumber: Health Canada

Bahan aktif:

PINDOLOL

Tersedia dari:

TEVA CANADA LIMITED

Kode ATC:

C07AA03

INN (Nama Internasional):

PINDOLOL

Dosis:

5MG

Bentuk farmasi:

TABLET

Komposisi:

PINDOLOL 5MG

Rute administrasi :

ORAL

Unit dalam paket:

100/500

Jenis Resep:

Prescription

Area terapi:

BETA-ADRENERGIC BLOCKING AGENTS

Ringkasan produk:

Active ingredient group (AIG) number: 0112362001; AHFS:

Status otorisasi:

APPROVED

Tanggal Otorisasi:

2011-09-15

Karakteristik produk

1
PRODUCT MONOGRAPH
PR
TEVA-PINDOLOL
Pindolol
5 mg, 10 mg and 15 mg Tablets
USP
Antihypertensive/Antianginal Agent
Teva Canada Limited
Date of Revision:
30 Novopharm Court
April 23, 2019
Toronto, Ontario
Canada M1B 2K9
www.tevacanada.com
Control No: 225972
2
NAME OF DRUG
Pr
TEVA-PINDOLOL
Pindolol
5 mg, 10 mg and 15 mg Tablets
USP
THERAPEUTIC CLASSIFICATION
Antihypertensive/Antianginal Agent
ACTIONS
TEVA-PINDOLOL (pindolol) is a β-adrenergic-receptor-blocking agent
which possesses partial
agonist activity (intrinsic sympathomimetic activity - I.S.A.). It is
used in the treatment of
hypertension and/or the prophylaxis of angina pectoris.
Hypertension
The mechanism of the antihypertensive effect of pindolol has not been
established. Among the
factors that may be involved are:
a)
competitive ability to antagonize catecholamine-induced tachycardia at
the β-receptor
sites in the heart, thus decreasing cardiac output
b)
a reduction in total peripheral resistance
c)
inhibition of the vasomotor centres
d)
inhibition of renin release by the kidneys
Angina Pectoris
The mechanism of the antianginal effect of pindolol has not been
established. Pindolol may
reduce the oxygen requirement of the heart at any level of effort by
blocking catecholamine-
induced increases in the heart rate, systolic blood pressure, and the
velocity and extent of
myocardial contraction. However, oxygen requirements may be increased
by such actions as
increases in left ventricular fibre length, end diastolic pressure and
the systolic ejection period.
When the net effect is beneficial in patients with angina, it
manifests itself during exercise or
stress by delaying the onset of pain and reducing the incidence and
severity of anginal attacks.
In man, orally-administered pindolol is rapidly and almost completely
absorbed (≥ 95%) from
the gastrointestinal tract. The mean absolute bioavailability after
oral administration is about 87-
92%. Plasma levels of 10 to 30 nanogram/mL are associated with its
therapeutic efficacy.
Following single dose adminis