Tacarline Injection 1mg ml

Negara: Malaysia

Bahasa: Inggris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ADRENALINE ACID TARTRATE

Tersedia dari:

DUOPHARMA (M) SDN. BHD.

INN (Nama Internasional):

ADRENALINE ACID TARTRATE

Unit dalam paket:

10 Ampoules

Diproduksi oleh:

DUOPHARMA (M) SDN. BHD.

Selebaran informasi

Not Applicable

Karakteristik produk

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[REVISION DATE: 15.08.2019]
[DUOPHARMA (M) SDN BHD]
TACARLINE INJECTION 1MG/ML
DESCRIPTION:
TACARLINE INJECTION 1MG/ML: Clear, colourless and odourless solution
COMPOSITION:
Each ml contains Adrenaline Acid Tartrate 0.18% W/V
PHARMACODYNAMICS:
Adrenaline acts on both alpha and beta adrenergic receptors of tissues
innervated by sympathetic nerves, except the sweat glands and arteries
of the face. It is the most potent
alpha receptor activator. Adrenaline stimulates the heart to increased
output; raises the systolic blood pressure; lowers diastolic blood
pressure; relaxes bronchial spasm and
mobilises liver glycogen, resulting in hyperglycaemia and possibly
glycosuria.
PHARMACOKINETICS:
The effects after SC administration are produced within 5 minutes,
which is slower than from IM administration. Endogenous plasma
concentration in normal subjects are in the range
30-160 pg/ml. Rapidly taken up by the heart, spleen, several glandular
tissues, and adrenergic nerves; only metabolites are detectable in
CFS; readily crosses the placenta; protein
binding, about 50% bound to plasma proteins. Rapidly metabolized by
oxidative deamination & O-methylation followed by reduction of
glucuronic acid or sulphate conjugation.
INDICATION:
It is used in the emergency treatment of anaphylactic shock due to
reaction from insect bites and drugs and for symptomatic relief of
serum sickness, urticarial, pruritus, angioneurotic,
oedema, respiratory distress due to bronchospasm, and relief of
hypersensitivity reactions to drugs and other allergens.
RECOMMENDED DOSAGE:
_Usual adult and adolescent dose: _
Bronchodilator (S.C.) - Initially 200 to 500 mcg (0.2 to 0.5 mg)
(base) repeated every 20 minutes to 4 hours as needed, the dosage
being increased up to a maximum of 1 mg per
dose, if necessary.
Anaphylactic reactions (L.M. OR S.C.) - Initially 200 to 500 mcg (0.2
to 0.5 mg)(base) repeated every 10 to 15 minutes if necessary as
needed, the dosage being increased up to a
maximum of 1 mg per dose if necessary.
Vasopressor (anaphyla