Negara: Australia
Bahasa: Inggris
Sumber: Department of Health (Therapeutic Goods Administration)
Ivermectin
Merck Sharp & Dohme Australia Pty Ltd
Medicine Listed (Export Only)
STROMECTOL ® _Ivermectin_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about STROMECTOL. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking STROMECTOL against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT STROMECTOL IS USED FOR STROMECTOL is used to treat river blindness (onchocerciasis) and threadworm involving the intestines (intestinal strongyloidiasis). These are caused by worm infections. In onchocerciasis the worm infection mainly affects the skin, glands (lymph nodes) and eyes. Changes to the skin may include an itchy rash, pale or dark patches, nodules (small lumps under the skin), thickening of the skin and/or loss of elasticity. The infection can cause enlarged glands in the neck, armpits or groin. The infection can also affect the eye and may cause conjunctivitis, a gritty or painful eye and may lead to blindness. In the form of strongyloidiasis that is treated with STROMECTOL, the worm infection mainly affects the intestines and skin. Symptoms which may occur include itchy rash, vomiting, diarrhoea and stomach pain. STROMECTOL works by killing the developing worms. STROMECTOL is also used to treat scabies which is caused by the Sarcoptes scabiei mite. Infection with the scabies mite causes discomfort and often intense itching of the skin, particularly at night, with irritating blisters or lumps on the skin. Classical sites of infestation are between the fingers, the wrists, underarm areas, female breasts (particularly the skin of the nipples), stomach area, penis, scrotum, and buttocks. Infants are usually affected on the face, scalp, palms and soles. Scabies is usually spread person to person via direct skin contact, includin Baca dokumen lengkapnya
IPC-MK0933-T-062010 1 PRODUCT INFORMATION STROMECTOL TABLETS (ivermectin 3 mg) NAME OF THE MEDICINE STROMECTOL ® (ivermectin) 3 mg tablet DESCRIPTION Ivermectin is derived from the avermectins, a class of highly active broad-spectrum antiparasitic agents isolated from fermentation broths of _Streptomyces avermitilis_. Ivermectin is a white to yellowish-white non-hygroscopic crystalline powder which is practically insoluble in water, freely soluble in methanol, and soluble in 95% ethanol. The structural and molecular formulae follow. Molecular Formulae: Molecular Weight: 22, 23-dihydroavermectin B1 a C48H74O14 (R=C2H5) 875.10 22, 23-dihydroavermectin B1 b C47H72O14 (R=CH3) 861.07 Ivermectin contains a minimum of 90% of 22, 23-dihydroavermectin B1 a (where the R group is ethyl) and a maximum of 10% of 22, 23-dihydroavermectin B1 b (the R group is methyl). STROMECTOL is supplied as a 3 mg tablet. STROMECTOL tablets also contain microcrystalline cellulose, pregelatinised maize starch, magnesium stearate, butylated hydroxyanisole and citric acid anhydrous. IPC-MK0933-T-062010 2 PHARMACOLOGY Ivermectin inhibits signal transmission from the ventral cord interneurons to the excitatory motor neurones in nematodes by stimulating release of the inhibitory neurotransmitter, gamma- aminobutyric acid (GABA) from pre-synaptic nerve terminals. In arthropods, a similar mechanism inhibits signal transmission at the neuromuscular junction. Ivermectin does not readily penetrate the CNS of mammals, and thus does not interfere with mammalian GABA-dependent neurotransmission. PHARMACOKINETICS: Absorption and Distribution: Ivermectin is incompletely absorbed (~50% bioavailable relative to an oral hydroalcoholic solution) following oral doses Baca dokumen lengkapnya