SODIUM CHLORIDE injection solution concentrate

Negara: Amerika Serikat

Bahasa: Inggris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

SODIUM CHLORIDE (UNII: 451W47IQ8X) (SODIUM CATION - UNII:LYR4M0NH37, CHLORIDE ION - UNII:Q32ZN48698)

Tersedia dari:

Hospira, Inc.

INN (Nama Internasional):

SODIUM CHLORIDE

Komposisi:

SODIUM CHLORIDE 234 mg in 1 mL

Jenis Resep:

PRESCRIPTION DRUG

Status otorisasi:

unapproved drug other

Karakteristik produk

SODIUM CHLORIDE- SODIUM CHLORIDE INJECTION, SOLUTION, CONCENTRATE
HOSPIRA, INC.
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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23.4%
SODIUM CHLORIDE
INJECTION, USP
400 MEQ/100 ML (4 MEQ/ML)
GLASS FLIPTOP VIALS
CONCENTRATE
_CAUTION: MUST BE DILUTED FOR I.V. USE._
Rx only
PHARMACY BULK PACKAGE –
NOT FOR DIRECT INFUSION
DESCRIPTION
23.4% Sodium Chloride Injection, USP is a sterile, nonpyrogenic,
concentrated solution of sodium
chloride in Water for Injection, USP.
Each mL contains sodium chloride, 234 mg (4 mEq/mL). The solution
contains no bacteriostat,
antimicrobial agent or added buffer. The specific gravity is 1.15, and
the osmolarity is 8008 mOsmol/L
(calc.). The additive may contain sodium hydroxide and/or hydrochloric
acid for pH adjustment. The pH
is 5.0 (4.5 to 7.0).
Sodium Chloride, USP is chemically designated NaCl, a white
crystalline compound freely soluble in
water. The molecular weight is 58.44.
The Pharmacy Bulk Package is a sterile dosage form which contains
multiple single doses for
preparation of admixtures for intravenous infusion (see DOSAGE AND
ADMINISTRATION,
Directions for Dispensing).
CLINICAL PHARMACOLOGY
Sodium chloride is an electrolyte replenisher. Sodium is the principal
cation of extracellular fluid. With
a normal plasma concentration of 142 mEq/L, sodium comprises more than
90% of the total plasma
cations. While sodium can diffuse across membranes, the intracellular
sodium concentration is
maintained at a much lower level than extracellular concentrations-the
so-called "sodium pump".
Compensation for loss of intracellular potassium occurs through an
increase in intracellular sodium.
Sodium is the principal ion that determines osmotic pressure of
interstitial fluids and the degree of
tissue hydration.
Adult serum chloride values typically range from 100 to 106 mEq/L.
Serum chloride levels decrease in
metabolic alkalosis, as serum bicarb