METHOCARBAMOL- methocarbamol tablet, film coated

Negara: Amerika Serikat

Bahasa: Inggris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

Methocarbamol (UNII: 125OD7737X) (Methocarbamol - UNII:125OD7737X)

Tersedia dari:

Proficient Rx LP

INN (Nama Internasional):

Methocarbamol

Komposisi:

Methocarbamol 750 mg

Rute administrasi :

ORAL

Jenis Resep:

PRESCRIPTION DRUG

Indikasi Terapi:

Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man. Methocarbamol is contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.

Ringkasan produk:

Methocarbamol Tablets USP, 750 mg — Yellow, film coated, modified capsule shaped tablets; one side debossed 'AP211' and other side blank. Available in bottles of 20, 30, 60 and 90. Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Dispense in a tight container.

Status otorisasi:

Abbreviated New Drug Application

Karakteristik produk

METHOCARBAMOL- METHOCARBAMOL TABLET, FILM COATED
PROFICIENT RX LP
----------
METHOCARBAMOL TABLET, FILM COATED
500 MG AND 750 MG
DESCRIPTION
Methocarbamol Tablets USP, 500 mg and 750 mg, a carbamate derivative
of guaifenesin, is a central
nervous system (CNS) depressant with sedative and musculoskeletal
relaxant properties.
The chemical name of methocarbamol is 3-(2-methoxyphenoxy)-1,
2-propanediol 1-carbamate and has
the empirical formula C
H NO . Its molecular weight is 241.24. The structural formula is shown
below.
Methocarbamol is a white powder, sparingly soluble in water and
chloroform, soluble in alcohol (only
with heating) and propylene glycol, and insoluble in benzene and
n-hexane.
Methocarbamol tablet, 500 mg is available as an orange, film coated,
round convex tablet containing 500
mg of methocarbamol, USP for oral administration. The inactive
ingredients present are
microcrystalline cellulose, croscarmellose sodium, FD&C Yellow 6
aluminum lake, hydroxypropyl
cellulose, hypromellose, magnesium stearate, polyethylene glycol,
triacetin, titanium dioxide.
Methocarbamol tablet, 750 mg is available as a yellow, film coated,
modified capsule shaped tablet
containing 750 mg of methocarbamol, USP for oral administration. The
inactive ingredients present are
microcrystalline cellulose, croscarmellose sodium, iron oxide yellow,
iron oxide red, hydroxypropyl
cellulose, hypromellose, magnesium stearate, polyethylene glycol,
triacetin, titanium dioxide.
CLINICAL PHARMACOLOGY
The mechanism of action of methocarbamol in humans has not been
established, but may be due to
general central nervous system (CNS) depression. It has no direct
action on the contractile mechanism
of striated muscle, the motor end plate or the nerve fiber.
PHARMACOKINETICS
In healthy volunteers, the plasma clearance of methocarbamol ranges
between 0.20 and 0.80 L/h/kg, the
mean plasma elimination half-life ranges between 1 and 2 hours, and
the plasma protein binding ranges
between 46% and 50%.
Methocarbamol is metabolized via dealkylation and h