Negara: Kanada
Bahasa: Inggris
Sumber: Health Canada
VERAPAMIL HYDROCHLORIDE
ABBOTT LABORATORIES, LIMITED
C08DA01
VERAPAMIL
120MG
TABLET
VERAPAMIL HYDROCHLORIDE 120MG
ORAL
250
Prescription
MISCELLANEOUS CALCIUM-CHANNEL BLOCKING AGENTS
Active ingredient group (AIG) number: 0113846001; AHFS:
CANCELLED POST MARKET
2007-07-31
PRODUCT MONOGRAPH ISOPTIN ® (verapamil hydrochloride) 80 mg and 120 mg Tablets _Antianginal/Antiarrhythmic/Antihypertensive Agent_ Abbott Laboratories, Limited DATE OF PREPARATION: 8401 Trans Canada Highway April 5, 2001 Saint-Laurent (QC) CANADA H4S 1Z1 DATE OF REVISION: February 19, 2004 Control No.: 088765 - 2 - NAME OF DRUG ISOPTIN ® (verapamil hydrochloride) 80 mg and 120 mg Tablets THERAPEUTIC CLASSIFICATION Antianginal/Antiarrhythmic/Antihypertensive Agent ACTION AND CLINICAL PHARMACOLOGY ANGINA AND ARRHYTHMIA ISOPTIN ® (verapamil hydrochloride) is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). The mechanism of the antianginal and antiarrhythmic effects of verapamil is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium through the slow channel (calcium ion antagonism) without affecting to any significant degree the transmembrane influx of sodium through the fast channel. This results in a reduction of free calcium ions available within cells of the above tissues. Verapamil's antiarrhythmic effects are believed to be brought about largely by its action on the sinoatrial (S-A) and atrioventricular (A-V) nodes. Verapamil depresses A-V nodal conduction and prolongs functional refractory periods. Verapamil does not alter the normal atrial action potential or intraventricular conduction time, but depresses amplitude, velocity of depolarization and conduction in depressed atrial fibres. Through this action, it interrupts re-entrant pathways and slows the ventricular rate. Verapamil may shorten the antegrade effective refractory period of the accessory bypass tract. Acceleration of ventricular rate and/or ventricular fibrillation has been reported in patients with atrial flutter or atrial fibrillation and a coexisting accessory A-V pathway following administration Baca dokumen lengkapnya