ISOMONIT

Negara: Australia

Bahasa: Inggris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Isosorbide mononitrate

Tersedia dari:

Sandoz Pty Ltd

Kelas:

Medicine Registered

Selebaran informasi

 
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ISOMONIT
®

isosorbide mononitrate (i-SO-sor-bide mo-no-NI-trat) 60 mg tablet 
CONSUMER MEDICINE INFORMATION 
WHAT IS IN THIS LEAFLET 

This leaflet answers some common questions about Isomonit. 
It does not contain all the available information. It does
not take the place of talking to 
your doctor or pharmacist.  

All medicines have risks and benefits. Your doctor has weighed
the risk of you taking 
Isomonit against the benefits it is expected to have
for you. 

IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST. 
KEEP THIS LEAFLET WITH THE MEDICINE. You
may want to read it again. 

WHAT ISOMONIT IS USED FOR 

The name of your medicine is
Isomonit. It contains the active ingredient isosorbide 
mononitrate. 

Isomonit is used to prevent angina pectoris (heart pain). It
is not recommended and should 
not be taken for the treatment of acute attacks.  

Your doctor may have prescribed Isomonit for another
reason. ASK YOUR DOCTOR IF YOU 
HAVE ANY QUESTIONS ABOUT WHY ISOMONIT WAS PRESCRIBED FOR YOU. 

_HOW ISOMONIT WORKS _

Isomonit belongs to a group of medicines
called nitrates. Isomonit reduces the amount of 
work the heart has to do. It does this by
increasing the size of the blood vessels around the 
heart. This also improves the blood flow around the heart
which means there is more oxygen 
being carried by the blood. This combination of actions reduces
the pain associated with 
angina. 

There is no evidence that Isomonit is addictive. 

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BEFORE YOU TAKE ISOMONIT 
_WHEN YOU MUST NOT TAKE ISOMONIT _

DO NOT TAKE ISOMONIT IF: 

•  you are allergic to the active ingredient
isosorbide mononitrate or any of the inactive 
ingredients mentioned at the end of this leaflet under Product
Des

Karakteristik produk

_Product Information  _
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PRODUCT INFORMATION 

ISOMONIT 

NAME OF THE MEDICINE 

ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS 

DESCRIPTION 

Chemical name: 1,4:3,6-dianhydro-D-glucitol 5-nitrate.   
Empirical formula: C
6
H
9
NO
6
.   
MW: 191.14. 
CAS no.  16051-77-7 

Chemical 
structure: 
    CH
2

HC – ONO
2
 O 

CH 

HC 

      O 
HC 
– 
OH 

CH
2 

Isosorbide mononitrate is a white to pale yellow, crystalline,
odourless powder that is 
freely soluble in water. 
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Isomonit Isosorbide Mononitrate 60 mg tablets contain 60 mg
isosorbide mononitrate, 
other ingredients are hypromellose, carnauba wax, stearic acid,
lactose, siliceous earth, 
magnesium stearate, talc–purified, titanium dioxide, iron oxide
yellow C177492 and 
macrogol 4000. 

PHARMACOLOGY 

Isosorbide mononitrate is an active metabolite of
isosorbide dinitrate and exerts 
qualitatively similar effects.  Isosorbide mononitrate reduces the
workload of the heart 
by producing venous and arterial dilatation.  By reducing the end
diastolic pressure and 
volume, isosorbide mononitrate lowers intramural pressure, hence
leading to an 
improvement in the subendocardial blood flow.  The net effect when
administering 
isosorbide mononitrate is therefore a reduced workload for the
heart and an 
improvement in the oxygen supply/demand balance of myocardium. 

Nitrates are highly effective in the prophylaxis of symptomatic and
asymptomatic 
myocardial ischaemia.  Nitrates dilate coronary arteries not only
in pre- and poststenotic 
vessels, but also in eccentric lesions.  The natural initiator of
vascular relaxation is 
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