Negara: Australia
Bahasa: Inggris
Sumber: Department of Health (Therapeutic Goods Administration)
Hydrochlorothiazide,Irbesartan
Sanofi-Aventis Australia Pty Ltd
Hydrochlorothiazide,Irbesartan
IRBESARTAN HCT WINTHROP ® _irbesartan & hydrochlorothiazide_ CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Irbesartan HCT Winthrop. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the benefits of you taking this medicine against the risks it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT IRBESARTAN HCT WINTHROP IS USED FOR Irbesartan HCT Winthrop is used to lower high blood pressure, which doctors call hypertension. Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are often no symptoms of high blood pressure. The only way of knowing that you have high blood pressure is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, such as stroke, heart disease and kidney failure. _HOW IRBESARTAN HCT_ _WINTHROP WORKS_ Irbesartan HCT Winthrop contains irbesartan and hydrochlorothiazide. Both medicines reduce blood pressure in different ways. Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body that causes blood vessels to narrow. Irbesartan blocks angiotensin-II and therefore widens your blood vessels, making it easier for your heart to pump blood throughout your body. This helps to lower your blood pressure. Hydrochlorothiazide belongs to the class of medicines known as diuretics. Diuretics cause an increase in the volume of urine. They also help with lowe Baca dokumen lengkapnya
PRODUCT INFORMATION Irbesartan HCT Winthrop - irbesartan hydrochlorothiazide Irbesartan-hct-winthrop-ccdsv13-piv7-29jun17 1 PRODUCT INFORMATION IRBESARTAN HCT WINTHROP ® NAME OF MEDICINE AUSTRALIAN APPROVED NAME Irbesartan/Hydrochlorothiazide Irbesartan: 2-butyl-3-[(2'-(1 _H_ -tetrazol-5-yl)biphenyl-4-yl)methyl]-1,3-diazaspiro[4.4]non-1-en-4- one Hydrochlorothiazide: 6-chloro-3,4-dihydro-2 _H_ -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide CHEMICAL STRUCTURE The chemical structure of irbesartan is: The empiric formula is C 25 H 28 N 6 O and the molecular weight, 428.5. The CAS registry number for irbesartan is: CAS-138402-11-6. The chemical structure of hydrochlorothiazide is: The empiric formula is C 7 H 8 ClN 3 O 4 S 2 and the molecular weight, 297.7. N N O (CH 2 ) 3 CH 3 N N N N H N N S CL H H O O S H 2 N O O PRODUCT INFORMATION Irbesartan HCT Winthrop - irbesartan hydrochlorothiazide Irbesartan-hct-winthrop-ccdsv13-piv7-29jun17 2 The CAS registry number for hydrochlorothiazide is: CAS-58-93-5 DESCRIPTION Irbesartan HCT Winthrop (irbesartan/hydrochlorothiazide) is an oral antihypertensive agent combining a nonpeptide angiotensin II receptor (AT 1 subtype) antagonist, irbesartan, and a thiazide diuretic, hydrochlorothiazide. Irbesartan is a white to off-white crystalline powder. It is a relatively non-polar compound with a partition coefficient (octanol-water) of 10.1 at a pH of 7.4. Irbesartan is slightly soluble in alcohol and methylene chloride, and practically insoluble in water. Hydrochlorothiazide is a white crystalline powder. It is slightly soluble in water but freely soluble in sodium hydroxide solution. Irbesartan HCT Winthrop 150/12.5 tablets contain 150 mg of irbesartan and 12.5 mg of hydrochlorothiazide and are peach to mottled peach coloured biconvex, oval-shaped, film-coated tablets debossed with a heart on one side and the number “2875” engraved on the other side. Irbesartan HCT Winthrop 300/12.5 tablets contain 300 mg of irbesartan and 12.5 mg of hydrochlorothiazide and are peach to mot Baca dokumen lengkapnya