Negara: Malaysia
Bahasa: Inggris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METFORMIN HYDROCHLORIDE
MILRIN PHARMACEUTICAL CO. (M) SDN BHD
METFORMIN HYDROCHLORIDE
10 blister x 10tablet Tablets
The United Drug (1996) Co.,Ltd.
GLUMIL 850MG TABLET Metformin Hydrochloride 850mg 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Glumil is used for 2. How Glumil works 3. Before you use Glumil 4. How to use Glumil 5. While you are using it 6. Side effects 7. Storage and Disposal of Glumil 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT GLUMIL IS USED FOR Glumil is used for the treatment of type 2 diabetes. HOW GLUMIL WORKS Glumil decrease hepatic glucose production, decreasing intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilization). BEFORE YOU USE GLUMIL - _When you must not use it _ Glumil should not be used by anyone who is allergic to any of the ingredients of the medication. Do not take Glumil : If you have severely reduced kidney function. If you have lactic acidosis [Too much lactic acid in the blood (see “Risk of lactic acidosis” below)] or ketoacidosis. Ketoacidosis is a condition in which substances called ‘ketone bodies’ accumulate in the blood and which can lead to diabetic pre-coma. Symptoms of acidosis may include stomach pain, abnormal breathing and drowsiness (if severe). - _Before you start use it _ _ _ Inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast- feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Risk of lactic acidosis Glumil may cause a very rare, but very serious side effect called lactic acidosis, particularly if your kidneys are not working properly. The risk of developing lactic acidosis is also increased with uncontrolled diabetes, serious infections, prolonged fasting or alcohol intake, dehydration, liver problems and any medical conditions in which a part of the body has a reduced supply of oxygen ( such as acute severe heart disease) If any of the above apply to you, talk to your doctor for Baca dokumen lengkapnya
GLUMIL 850mg Tablet Metformin HCl 850mg PRODUCT NAME : Glumil 850 mg Tablet NAME AND STRENGTH OF ACTIVE SUBSTANCE : Each tablet contains : Metformin Hydrochloride 850 mg PRODUCT DESCRIPTION : Round, biconvex, white film-coated tablet, engraved “850” on one side, and scored on another side. PHARMACODYNAMICS : Metformin hydrochloride is a biguanide oral antihyperglycemic drug used in the management of type 2 diabetes mellitus. It decreased hepatic glucose production, decreasing intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilization). PHARMACOKINETICS : The absolute bioavailability of Metformin is approximately 50% to 60%. The apparent volume of distribution (V/F) following single oral doses of Metformin hydrochloride 850 mg averaged 654±358 L. Metformin is negligibly bound to plasma proteins, in contrast to sulfonylureas, which are more than 90% protein bound. At usual clinical doses and dosing schedules, steady- state plasma concentrations of Metformin are reached within 24 to 48 hours and are generally less than 1 µg/mL. Metformin is excreted unchanged in the urine. Following oral administration, approximately 90% of the absorbed drug is eliminated in the unchanged form via the renal route within the first 24 hours, with a plasma elimination half-life of approximately 6.2 hours. INDICATIONS : Glumil 850 mg Tablet is an oral antidiabetic agent (biguanide) intended for the treatment of type 2 diabetes. Glumil 850 mg Tablet may be given alone or with oral antidiabetic agents, or with insulin. A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet therapy. RECOMMENDED DOSAGE : The dosage of Glumil 850 mg Tablet is determined by your doctor on an individual basis according to the results of laboratory blood glucose measurement. The initial dosage may be increased as necessary to be one tablet 2 or 3 times daily in adults. The maximum recommended dose i Baca dokumen lengkapnya