GLIPIZIDE AND METFORMIN HYDROCHLORIDE tablet film coated

Negara: Amerika Serikat

Bahasa: Inggris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

GLIPIZIDE (UNII: X7WDT95N5C) (GLIPIZIDE - UNII:X7WDT95N5C)

Tersedia dari:

St Marys Medical Park Pharmacy

INN (Nama Internasional):

GLIPIZIDE

Komposisi:

GLIPIZIDE 2.5 mg

Jenis Resep:

PRESCRIPTION DRUG

Status otorisasi:

Abbreviated New Drug Application

Karakteristik produk

GLIPIZIDE AND METFORMIN HYDROCHLORIDE - GLIPIZIDE AND METFORMIN
HYDROCHLORIDE TABLET, FILM COATED
ST MARYS MEDICAL PARK PHARMACY
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GLIPIZIDE AND METFORMIN HYDROCHLORIDE TABLETS USP
DESCRIPTION
Glipizide and metformin hydrochloride tablets USP contain 2 oral
antihyperglycemic drugs used in the
management of type 2 diabetes, glipizide and metformin hydrochloride.
Glipizide is an oral antihyperglycemic drug of the sulfonylurea class.
The chemical name for glipizide
is
1-cyclohexyl-3-[[_p_-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea.
Glipizide is a
whitish, odorless powder with a pK of 5.9. It is insoluble in water
and alcohols, but soluble in 0.1 _N_
NaOH; it is freely soluble in dimethylformamide. The structural
formula is represented below.
C
H N O S M.W. 445.55
Metformin hydrochloride is an oral antihyperglycemic drug used in the
management of type 2 diabetes.
Metformin hydrochloride (_N_,_N-_dimethylimidodicarbonimidic diamide
monohydrochloride) is not
chemically or pharmacologically related to sulfonylureas,
thiazolidinediones, or α-glucosidase
inhibitors. It is a white to off-white crystalline compound. Metformin
hydrochloride is freely soluble in
water and is practically insoluble in acetone, ether, and chloroform.
The pK of metformin is 12.4. The
pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The
structural formula is as shown:
C H ClN M.W. 165.63
Glipizide and metformin hydrochloride is available for oral
administration in tablets containing 2.5 mg
glipizide with 250 mg metformin hydrochloride, 2.5 mg glipizide with
500 mg metformin
hydrochloride, and 5 mg glipizide with 500 mg metformin hydrochloride.
In addition, each tablet
contains the following inactive ingredients: corn starch,
croscarmellose sodium, magnesium stearate,
microcrystalline cellulose, polyethylene glycol, polyvinyl
alcohol-part. hydrolyzed, povidone, talc, and
titanium dioxide. Additionally, 2.5 mg/250 mg and 5 mg/500 mg tablets
contain iron oxide black, iron
oxide red, and iron oxide yellow. The