Esipram

Negara: Australia

Bahasa: Inggris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Escitalopram oxalate

Tersedia dari:

CNS Pharma Pty Ltd

Kelas:

Medicine Registered

Selebaran informasi

ESIPRAM
®

(ES-E-PRAM)
_Escitalopram oxalate (ES-sigh-talo-pram OX-a-late)_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet contains answers to some
common questions about Esipram.
It does not contain all the information
that is known about Esipram. It does
not take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risk of you using this medicine
against the benefits he/she expects it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT ESIPRAM IS USED
FOR
Esipram is used to treat depression.
It belongs to a group of medicines
called selective serotonin reuptake
inhibitors (SSRIs). They are thought
to work by their actions on brain
chemicals called amines which are
involved in controlling mood.
Depression is longer lasting or more
severe than the "low moods"
everyone has from time to time due
to the stress of everyday life. It is
thought to be caused by a chemical
imbalance in parts of the brain. This
imbalance affects your whole body
and can cause emotional and physical
symptoms such as feeling low in
spirit, loss of interest in activities,
being unable to enjoy life, poor
appetite or overeating, disturbed
sleep, often waking up early, loss of
sex drive, lack of energy and feeling
guilty over nothing.
Esipram corrects this chemical
imbalance and may help relieve the
symptoms of depression.
Esipram may also be used to treat
patients who may avoid and/or are
fearful of social situations.
Esipram may also be used to treat
patients who have excessive anxiety
and worry.
Esipram may also be used to treat
irrational fears or obsessional
behaviour (obsessive-compulsive
disorder). Obsessive-compulsive
disorder involves having both
obsessions and compulsions.
Obsessions are unwanted thoughts
that occur over and over again.
Compulsions are the ongoing need to
repeat certain actions as a result of

Karakteristik produk

Esipram PI 24 May 2013 v2 

Page 1 of 26 
PRODUCT INFORMATION 

ESIPRAM 

NAME OF THE MEDICINE: 
Escitalopram oxalate 

Chemical name: 
S(+)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-
carbonitrile hydrogen oxalate.   

Chemical Abstracts No: 
219861-08-2 

Molecular formula and weight: 
C
20
H
21
FN
2
O, C
2
H
2
O
4
: 414.42 

Structural formula: 

NC
O
CH
2
CH
2
CH
2
N(CH
3
)
2
     , HOOCCOOH
F

DESCRIPTION: 

Escitalopram  is  the  active  enantiomer  (s-enantiomer)  of  citalopram.    Escitalopram 
oxalate is a fine white to yellow, crystalline material. 

Escitalopram oxalate is sparingly soluble in water, slightly soluble in acetone, soluble 
in ethanol and freely soluble in methanol.  No polymorphic forms have been detected. 

Excipients  in  tablets:  cellulose-microcrystalline,  silica  -  colloidal  anhydrous,  talc  - 
purified,  croscarmellose  sodium,  magnesium  stearate,  hypromellose,  macrogol  400 
and titanium dioxide. 

PHARMACOLOGY: 

Pharmacological actions 

Biochemical  and  behavioural  studies  have  shown  that  escitalopram  is  a  potent 
inhibitor of serotonin (5-HT)-uptake (_in vitro_ IC
50
 2nM). 

Esipram PI 24 May 2013 v2 

Page 2 of 26 
The antidepressant  action of escitalopram is presumably linked to the potentiation of 
serotonergic  activity  in  the  central  nervous  system  (CNS)  resulting  from  its  inhibitory 
effect on the reuptake of 5-HT from the synaptic cleft. 

Escitalopram is a highly selective Serotonin Reuptake Inhibitor
(SSRI). On the basis of 
_in  vitro_  studies,  escitalopram  had  no,  or  minimal  effect  on  noradrenaline  (NA), 
dopamine (DA) and gamma aminobutyric acid (GABA) uptake. 

In contrast to many tric