Negara: Malaysia
Bahasa: Inggris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
GLIBENCLAMIDE; METFORMIN HYDROCHLORIDE
HOVID BERHAD
GLIBENCLAMIDE; METFORMIN HYDROCHLORIDE
120Tablet Tablets; 10 Tablets; 100 Tablets
HOVID BERHAD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ DIAMIDE FILM-COATED TABLET Glibenclamide/Metformin (5/500 mg, 2.5/500 mg) 1 WHAT IS IN THIS LEAFLET 1. What Diamide tablet is used for 2. How Diamide tablet works 3. Before you use Diamide tablet 4. How to use Diamide tablet 5. While you are using Diamide tablet 6. Side effects 7. Storage and Disposal of Diamide tablet 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial number WHAT DIAMIDE TABLET IS USED FOR This anti-diabetic medication is a combination of two drugs (glibenclamide and metformin). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes (non- insulin-dependent diabetes). HOW DIAMIDE TABLET WORKS Diamide tablet combines two glucose- lowering drugs, glibenclamide and metformin. These two drugs work together to improve the different metabolic defects found in type 2 diabetes. Glibenclamide lowers blood sugar primarily by causing more of the body's own insulin to be released, and metformin lowers blood sugar, in part, by helping your body use your own insulin more effectively. Together, they are efficient in helping you to achieve better glucose control. BEFORE YOU USE DIAMIDE TABLET _- When you must not use it _ You should not take Diamide tablet if: • You have kidney or liver problems • You have congestive heart failure which is treated with medications, eg, digoxin or furosemide • You drink alcohol excessively (all the time or short-term "binge" drinking) • You are seriously dehydrated (have lost a large amount of body fluids) • You are going to have surgery • You develop a serious condition, such as a heart attack, severe infection, or stroke. • You have severely reduced kidney function. • You have lactic acidosis (too much lactic acid in the blood. See “risk of lactic acidosis” below or ketoacidosis. Ketoacidosis is a condition in which substances called ‘ketone bodies’ accumulate in the blood and which can lead to dia Baca dokumen lengkapnya
DESCRIPTION DIAMIDE 2.5 MG / 500 MG FILM-COATED TABLET White, oblong, transparent film-coated tablet, shallow convex faces, "HD" embossed and scored at the same face. DIAMIDE 5 MG / 500 MG FILM-COATED TABLET Oblong, yellow film-coated tablet, shallow convex faces, "HD" embossed and scored at the same face. COMPOSITION Each tablet contains: DIAMIDE 2.5 MG / 500 MG FILM-COATED TABLET Glibenclamide 2.5 mg, Metformin HCl 500 mg DIAMIDE 5 MG / 500 MG FILM-COATED TABLET Glibenclamide 5 mg, Metformin HCl 500 mg PHARMACODYNAMICS GLIBENCLAMIDE: Glibenclamide is a sulfonylurea antidiabetic. It promotes the increased secretion of insulin from the beta cells of islet tissue in the pancreas by means of a process not yet specifically defined. The overall effect is a reduction in blood glucose concentration only in those patients whose pancreas is capable of synthesizing insulin. Oral antidiabetic medications apparently do not influence the production of insulin by the beta cells but seem to enhance its release from these pancreatic cells. METFORMIN HYDROCHLORIDE: Metformin is an oral biguanide antidiabetic agent. Its mode of action is thought to be multifactorial and includes delayed uptake of glucose from the gastro-intestinal tract; increased peripheral glucose utilization mediated by increased insulin sensitivity; and inhibition of increased hepatic and renal gluconeogenesis. PHARMACOKINETICS GLIBENCLAMIDE: Glibenclamide is readily absorbed from the gastrointestinal tract, peak plasma concentrations usually occurring within 2 to 4 hours, and is extensively bound to plasma proteins. Absorption may be slower in hyperglycaemic patients and may differ according to the particle size of the preparation used. It is metabolized, almost completely, in the liver, the principal metabolite being only very weakly active. Approximately 50% of a dose is excreted in the urine and 50% via the bile into the faeces. METFORMIN HYDROCHLORIDE: Metformin Hydrochloride is slowly and incompletely absorbed from the gastrointestinal tract. The absolu Baca dokumen lengkapnya