DBL PETHIDINE HYDROCHLORIDE

Negara: Australia

Bahasa: Inggris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Pethidine hydrochloride

Tersedia dari:

Hospira Australia Pty Ltd

Kelas:

Medicine Registered

Selebaran informasi

DBL™ Pethidine Hydrochloride Injection BP 

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DBL™ PETHIDINE HYDROCHLORIDE 
INJECTION BP 

Pethidine _(PETH-E-DEEN) _

CONSUMER MEDICINE INFORMATION 
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WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about DBL™ 
Pethidine Hydrochloride Injection 
BP. 

It does not contain all the 
available information. 

It does not take the place of 
talking to your doctor or 
pharmacist. 

All medicines have risks and 
benefits
.
 Your doctor or 
pharmacist has weighed the risks 
of you being given DBL™ 
Pethidine Hydrochloride Injection 
BP against the benefits they 
expect it will have for you. 

IF YOU HAVE ANY CONCERNS ABOUT 
THIS MEDICINE, ASK YOUR DOCTOR 
OR PHARMACIST. 

Keep this leaflet in a safe place. 
You may need to read it again. 

WHAT DBL™ PETHIDINE 
HYDROCHLORIDE 
INJECTION BP IS USED 
FOR 

In some overseas countries, 
pethidine is called meperidine. 

Pethidine is a pain killer that 
belongs to a group of medicines 
called opioid analgesics.  
Pethidine acts in the brain and 
the spinal cord. 

Pethidine is most commonly used 
to relieve severe pain. It may also 
be used just before, or during, an 
operation, to help the anaesthetic 
work better. 

Your doctor may have prescribed 
pethidine for another reason.  Ask 
your doctor if you have any 
questions about why pethidine 
has been prescribed for you. 

Pethidine may produce physical 
dependency if used for a long 
time (ie more than two weeks). 
Physical dependency means you 
may experience unpleasant 
feelings if you stop pethidine 
suddenly. 

However, it is also important to 
keep your pain under control. 
Your doctor can advise you on 
how to prevent and manage this. 

This medicine is available only 
with a doctor’s prescription. 

BEFORE YOU ARE GIVEN 
DBL™

PETHIDINE 
HYDRO

Karakteristik produk

Product Information – Australia 

Version 7.0 
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DBL™ PETHIDINE HYRDOCHLORIDE INJECTION BP 

NAME OF THE MEDICINE 
Pethidine hydrochloride 

Chemical name:  ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
hydrochloride (MW 283.8).  CAS_ _
Registry Number:  50-13-5. 

The chemical structure of Pethidine Hydrochloride is: 

N
CH
3
COOCH
2
CH
3
, HCl

DESCRIPTION 
Pethidine Hydrochloride is a white crystalline powder, very soluble
in water and freely soluble in 
alcohol. DBL™ Pethidine Hydrochloride Injection BP is a sterile,
clear solution of Pethidine 
Hydrochloride BP in Water for Injections BP. The 50 mg/1 mL and 100
mg/2 mL presentations 
contain sodium hydroxide.  The pH of the injection ranges between
3.5 and 6.0. 

PHARMACOLOGY 
Pethidine is a synthetic opioid analgesic which produces a pattern of
effects similar to morphine, the 
standard against which opioid analgesics are compared.  In addition
to analgesia, the effect of 
pethidine on the central nervous system causes
respiratory depression, drowsiness, sedation, change in 
mood, euphoria, dysphoria, mental clouding, nausea, vomiting, and
electroencephalographic changes.  
Large doses of pethidine may induce excitation or convulsions.
 Pethidine is not effective in the 
management of cough or diarrhea. 

As a general rule, 75 to 100 mg pethidine (parenterally) is
equivalent to 10 mg morphine with respect 
to analgesic effect, euphoria and respiratory depression. 

Pethidine has local anaesthetic activity but may be irritant when
applied locally. 

Opioids exert their pharmacological actions by interaction with
stereo-specific opiate receptors 
located in the central and peripheral nervous systems. 

PHARMACOKINETICS 
ABSORPTION:  Pethidine may be administered as an intramuscular,
intravenous or subcutaneous 
injection.  Variable absorption has been observed in some cases
following intramuscular 
administration.  It has been found that 80%�