COXAN TABLET 500MG

Negara: Malaysia

Bahasa: Inggris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Paracetamol

Tersedia dari:

MILRIN PHARMACEUTICAL CO. (M) SDN BHD

INN (Nama Internasional):

Paracetamol

Unit dalam paket:

1000 Tablet Tablets; 100Tablet Tablets

Diproduksi oleh:

PRIME PHARMACEUTICAL SDN. BHD.

Selebaran informasi

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
_ _
COXAN TABLET 500MG
_Paracetamol 500mg_
_ _
1
WHAT IS IN THIS LEAFLET
1.
What Coxan is used for
2.
How Coxan works
3.
Before you use Coxan
4.
How to use Coxan
5.
While you are using Coxan
6.
Side effects
7.
Storage and Disposal of Coxan
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
1. WHAT COXAN IS USED FOR
Coxan is used for the relief of fever
and pain in adults and children.
2. HOW COXAN WORKS
Coxan
acts
in
the
brain
to
reduce
fever. Coxan also works to stop the
pain messages from getting through
to the brain.
3. BEFORE YOU USE COXAN
_- When you must not use it _
_ _
You should not take Coxan if you are
allergic to paracetamol or any of the
ingredients
in
this
medicine.
The
symptoms of an allergic reaction may
include:
-
Shortness of breath
-
Wheezing or difficulty breathing
-
Swelling of the face, lips, tongue
or other parts of the body
-
Rash, itching or hives on the skin
Do not take Coxan if you have liver
or kidney problems.
_- Before you start use it _
_ _
You
must
tell
your
doctor
or
pharmacist if you have or have had
any
of
the
following
medical
conditions:
-
You
have
allergies
to
any
ingredients of this medicine
-
You have allergies to aspirin or
any other NSAID medicine
-
You
have
liver
or
kidney
problems
-
Acute breathing difficulties such
as bronchitis, unstable asthma or
emphysema
-
You
drink
large
quantities
of
alcohol
_- Taking other medicines _
_ _
You
should
tell
your
doctor
or
pharmacist
if
you
are
taking
any
other medicines, including any that
you get without a prescription from a
pharmacy,
supermarket
or
health
food shop.
Some
medicine
and
Coxan
may
interfere
with
each
other.
These
include:
-
Alcohol,
hepatic
enzyme
inducers, hepatotoxic medications
-
Any
medicines
which
thin
the
blood, for example warfarin
-
NSAID medicines
4. HOW TO USE COXAN
_- How much to use _
_ _
Follow all instructions given to you
by
your
doctor
and
pharmacist
carefully. They may differ from the
information contained in

Karakteristik produk

COXAN
TM TABLET
DESCRIPTION
:
White circular, flat beveled-edge, uncoated tablet marked on one side
with letter ‘M’ on top half and ‘PL’ on
bottom half, other side marked ‘PARACETAMOL’.
CONTENT
Each tablet contains paracetamol 500mg.
INDICATIONS
For the relief of fever and pain.
PHARMACOLOGY
Paracetamol has analgesic and antipyretic effects. It may produce
analgesia by inhibiting prostaglandin synthesis in the
central nervous system and through a peripheral action by blocking
pain impulse generation. The peripheral action may also
be due to inhibition of the synthesis of prostaglandins or to
inhibition of the synthesis or action of other substance, which pain
receptors to mechanical or chemical stimulation sensitize. Paracetamol
probably produces antipyresis by acting centrally on
the hypothalamic heat regulating centre to produce peripheral
vasodilatation resulting in increased blood flow through the skin,
sweating and heat loss. The central action probably involves the
inhibition of prostaglandin synthesis in the hypothalamus.
The oral absorption of paracetamol is rapid and almost complete and
may be decreased if taken after a high carbohydrate
meal. Protein binding is not significant with doses producing plasma
concentration below 60mcg/ml but may reach moderate
level with high or toxic doses. Approximately 90% - 95% of a dose is
metabolized in the liver, primarily by conjugation with
glucuronic acid, sulphuric acid and cysteine. The half-life is 1 - 4
hours and dose not change with renal failure but may be
prolonged in some forms of hepatic disease, the elderly and neonates,
and may be somewhat shortened in children. The
duration of action is 3 - 4 hours. Excretion is renal, primarily as
conjugates and 3% of a dose maybe excreted unchanged.
ADVERSE EFFECTS
Side effects of paracetamol are usually mild, though hematological
reactions have been reported.
Cutaneous hypersensitivity reactions including skin rashes,
angioedema, Steven Johnson Syndrome/Toxic Epidermal
Necrolysis have been reported.
PRECA