AVM-Artrisa 500mg Capsule

Negara: Malaysia

Bahasa: Inggris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Glucosamine Sulfate Sodium, Crystalline

Tersedia dari:

AV MANUFACTURING SDN.BHD

INN (Nama Internasional):

Glucosamine Sulfate Sodium, Crystalline

Unit dalam paket:

60 Capsule Capsules; 14 Capsule Capsules; 28 Capsule Capsules

Diproduksi oleh:

AV MANUFACTURING SDN.BHD

Selebaran informasi

_ _
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
_ _
AVM-ARTRISA
® 500MG CAPSULE
Glucosamine Sulphate (500mg)
1 WHAT IS IN THIS LEAFLET
1.
What AVM-Artrisa
®
500mg Capsule
is used for
2.
How AVM-Artrisa
®
500mg Capsule
works
3.
Before you use AVM-Artrisa
®
500mg
Capsule
4.
How to use AVM-Artrisa
®
500mg
Capsule
5.
While you are using AVM-Artrisa
®
500mg Capsule
6.
Side effects
7.
Storage and disposal
8.
Product description
9.
Manufacturer and product
registration holder
10.
Date of revision
1.
WHAT AVM-ARTRISA
® 500MG
CAPSULE IS USED FOR
AVM-Artrisa
®
500mg Capsule is used to
relieve joint problems related to
osteoarthritis.
2.
HOW AVM-ARTRISA
® 500MG CAPSULE
WORKS
AVM-Artrisa
®
500mg Capsule contains
glucosamine which forms a key part of
cartilage (the cushioning substance between
bones in the joints). Glucosamine acts to
increase synovial fluid production, thereby
providing lubricant activity for proper joint
function.
3.
BEFORE YOU USE AVM-ARTRISA
®
500MG CAPSULE
_-When you must not use it_

If you are allergic to glucosamine or
any of the ingredients in the product.

If you are allergic to seafood.

Avoid use during the first 3 months of
pregnancy.
_-Before you start to use it_
Read the instruction and this leaflet
carefully to understand how this
medication should be taken.
Avoid use in children.
Tell your doctor or a pharmacist if you
have any medical conditions, especially
any of the following:

if
you
are
pregnant,
planning
to
become pregnant, or breastfeeding.

if
you
have
allergies
to
seafood,
medicines or other substances. This
product contains glucosamine sulfate,
a seafood-derived material. It is not
recommended for people with seafood
allergies.

if you have high blood glucose

if you have severe liver and /or kidney
problems
_-Taking other medicines_
Talk to your doctor or a pharmacist if
you are taking:

any medicine for diabetes (to control
the blood sugar), such as metformin,
acarbose, repaglinide.

Warfarin (a blood-thinning drug).
Glucosamine may incr

Karakteristik produk

AVM-ARTRISA
® 250MG CAPSULE
AVM-ARTRISA
® 500MG CAPSULE
NAME AND STRENGTH OF ACTIVE SUBSTANCE
AVM-ARTRISA
® 250MG CAPSULE: Crystalline glucosamine sulphate sodium chloride 314mg
equivalent to 250 mg
glucosamine sulphate (derived from seafood)
AVM-ARTRISA
® 500MG CAPSULE: Crystalline glucosamine sulphate sodium chloride 628mg
equivalent to 500 mg
glucosamine sulphate (derived from seafood)
PRODUCT DESCRIPTION
AVM-ARTRISA
® 250MG CAPSULE: Hard gelatin bovine origin capsule, snap fit red/white
opaque capsule with
printed ‘ART 250’ at both side.
AVM-ARTRISA
® 500MG CAPSULE: Hard gelatin bovine origin capsule, snap fit red/white
opaque capsule with
printed ‘ART 500’ at both side
PHARMACODYNAMICS
Glucosamine is a natural substance found in chitin, mucoproteins, and
mucopolysaccharides. It is involved in the
manufacture of glycosaminoglycan, which forms cartilage tissue in the
body; glucosamine is also present in
tendons and ligaments. Glucosamine must be synthesised by the body but
the ability to do this declines with age.
Glucosamine and its salts have therefore been advocated in the
treatment of rheumatic disorders including
osteoarthritis.
Glucosamine also acts to improve the viscosity of synovial fluid by
increasing synovial fluid production,
thereby providing lubricant activity.
PHARMACOKINETICS
_Absorption _
After oral administration, bioavailability is low due to first-pass
hepatic metabolism~26%
The gastrointestinal absorption is close to 90%
_Distribution _
Glucosamine is not protein-bound, but rather incorporates into plasma
proteins (primarily globulins) , Volume of
Distribution: 2.5 Liters
_Metabolism _
-Liver, extensive
The first-pass effect in the liver in which more than 70% of
glucosamine is metabolized.
_Excretion _
Renal Excretion, 10%; feces, 11%
Part of a dose of glucosamine sulfate is eliminated as carbon dioxide
via expired air
INDICATION
Adjuvant therapy for osteoarthritis
RECOMMENDED DOSAGE
Adults
1500 milligrams daily, single dose or in 3 divided doses. Dosing also
may be based on