Armida 1 mg Film-Coated Tablet

Negara: Filipina

Bahasa: Inggris

Sumber: FDA (Food And Drug Administration)

Bahan aktif:

Anastrozole

Tersedia dari:

The Cathay Drug Co., Inc.; Distributor: The Cathay Drug Co., Inc.

INN (Nama Internasional):

Anastrozole

Dosis:

1 mg

Bentuk farmasi:

Film-Coated Tablet

Unit dalam paket:

Osyter White HDPE Bottle of 14 Tablets, Oyster White HDPE Bottle (Box of 14 tablets)

Diproduksi oleh:

Yangtze River Pharmaceutical (Group) Co. Ltd., China

Tanggal Otorisasi:

2020-12-02

Selebaran informasi

ARMIDA
ARMIDA 1 mg
Film – Coated Tablet
(Anastrozole)
ANTINEOPLASTIC
Category: Oral
Description
The Cathay Drug Co., Inc.
ANASTROZOLE
FORMULATION
Each film – coated tablet contains:
Anastrozole
…………………………………………………………………………………………..
1mg
PHARMACODYNAMICS
Anastrozole is a potent and highly selective non-steroidal aromatase
inhibitor. In postmenopausal
women, estradiol is produced primarily from the conversion of
androstenedione to estrone through
the aromatase enzyme complex in peripheral tissues. Estrone is
subsequently converted to
estraidiol. Reducing circulating estradiol levels has been shown to
produce a beneficial effect in
women with breast cancer. In postmenopausal women, anastrozole at a
daily dose of 1 mg produced
estradiol suppression of greater than 80% using a highly sensitive
assay.
Anastrozole does not possess any progestogenic, androgenic or
estrogenic activity.
Daily doses of anastrozole up to 10 mg do not have any effect on
cortisol or aldosterone secreton,
measured before or after standard adrenocorticotropic hormone (ACTH)
challenge testing.
Corticoid supplements are therefore not needed.
PHARMACOKINETICS
Absorption of anastrozole is rapid while taken orally and maximum
plasma concentrations typically
occur within two hours of dosing (under fasted conditions). Anastozole
is only 40% bound to
plasma proteins and is extensively metabolized by postmenopausal women
with less than 10% of
the dose excreted in the urine unchanged within 72 hours of dosing.
Anastrozole is elimination
slowly with a plasma elimination half-life of 42.57+10.15 hours. Food
slightly decreases the rate
but not extent of absorption. The small change in the rate of
absorption is not expected to result in a
clinically significant effect on steady-state plasma concentrations
during once daily dosing of
anastrozole tablets. Approximately 90 to 95% of plasma anastrozole
steady-state concentrations are
attained after 7 daily doses. There is no evidence of time or