Advantan

Negara: Australia

Bahasa: Inggris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Methylprednisolone aceponate

Tersedia dari:

CSL Limited

Kelas:

Medicine Registered

Selebaran informasi

ADVANTAN(R)
1
ADVANTAN(R)
OINTMENT, FATTY OINTMENT, CREAM & LOTION
_Methylprednisolone aceponate (meth'il -predd -niz-oh -lone ass-epp
-on -eight)_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET?
PLEASE READ THIS LEAFLET CAREFULLY
BEFORE YOU START YOUR TREATMENT.
KEEP THIS LEAFLET.
You may want to read it again.
This leaflet answers some common
questions about using Advantan(R).
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using Advantan(R)
against the benefits it is expected to
have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING ADVANTAN(R), TALK TO YOUR
DOCTOR OR PHARMACIST.
WHAT ADVANTAN(R) IS
USED FOR
The active ingredient in Advantan(R)
belongs to the group of medicines
called corticosteroids. The
corticosteroid in Advantan(R) is
suitable to put on the skin. It is
therefore called a topical
corticosteroid, which is sometimes
shortened to topical steroid.
When Advantan(R) is put on the
skin, it relieves the redness, swelling,
itching and irritation of the skin in
eczema and psoriasis.
Advantan(R) preparations are
available only with a doctor's
prescription.
Advantan(R) is made up as four
different preparations. Each has a
distinct look and feel. They are:
*
ointment,
*
fatty ointment,
*
cream and
*
lotion.
The most solid is the fatty ointment;
the most runny is the lotion. The
ointment and cream are in-between in
thickness.
Each preparation is especially
suitable in consistency for a
particular area of skin or skin
condition needing treatment. Your
doctor will prescribe the preparation
most suitable for you.
The Advantan(R) preparations are
medicines and should only be used
on skin affected by the conditions
described below.
All four Advantan(R) preparations
treat eczema.
Advantan(R) ointment, fatty
ointment and cream (but NOT lotion)
also treat psoriasis.

Karakteristik produk

PRODUCT INFORMATION –
ADVANTAN
®
 OINTMENT, FATTY
OINTMENT,
CREAM & LOTION
NAME OF THE DRUG
The chemical name is 21-acetoxy-11
β-hydroxy-6α-methyl-17-propionyloxy-1, 4-
pregnadiene-3, 20-dione.
The chemical structure is
CH
3
O
O
H
CH
3
O
O
O
H
H
H
CH
3
O
O
The CAS registry number is 86401-95-8.  The molecular formula is C
27
H
36
O
7
.  The
molecular weight is 472.58.
DESCRIPTION
The active ingredient of the Advantan
®
 formulations is the synthetic corticosteroid
methylprednisolone aceponate (MPA), which is a white crystalline
powder.
Methylprednisolone aceponate is soluble in methylene chloride,
acetone and ethyl
acetate and is sparingly soluble in hexane and ether.
Advantan
®
 ointment is a water-in-oil emulsion containing 30% purified water.
 It also
contains white soft paraffin, heavy liquid paraffin, white beeswax and
Dehymuls E.
Advantan
®
 fatty ointment is a monophasic ointment with 96.9% hydrocarbons
(white
soft paraffin, heavy liquid paraffin, microcrystalline wax) and
hydrogenated castor oil.
Advantan
®
 cream is an oil-in-water emulsion containing about 60% purified
water.  It
also contains decyl oleate, glyceryl monostearate, cetostearyl
alcohol, hard fat, Softisan
378, PEG-40 stearate, glyceryl 85%, butylated hydroxytoluene,
benzyl alcohol, and
disodium edetate.
Advantan
®
 lotion is an oil-in-water emulsion containing 68% purified water.
 It also
contains medium chain triglycerides, caprylic/capric/stearic
triglycerides, steareth-2,
steareth-21, benzyl alcohol, disodium edetate and glycerol.
PHARMACOLOGY
PHARMACODYNAMICS
After topical application, Advantan
®
 (methylprednisolone aceponate) has anti-
inflammatory, anti-pruritic and vasoconstrictive actions.
As for all other glucocorticoids, the mechanism of action of
methylprednisolone
aceponate is not completely understood.  It is known that
methylprednisolone
aceponate binds to the intracellular glucocorticoid receptor as does
the principal
metabolite 6
α-methylprednisolone-17-propionate, which is formed by cleav