Negara: Australia
Bahasa: Inggris
Sumber: Department of Health (Therapeutic Goods Administration)
Nifedipine
Alphapharm Pty Ltd
Medicine Registered
ADEFIN XL _contains the active ingredient nifedipine_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about ADEFIN XL tablets. It is not to be used in relation to any other product, which may also contain the same active ingredient. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking ADEFIN XL against the benefits expected for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. PLEASE READ THIS LEAFLET CAREFULLY AND KEEP IT WITH YOUR MEDICINE. You may need to read it again. WHAT ADEFIN XL IS USED FOR ADEFIN XL is used to: • treat high blood pressure • prevent chronic stable angina, a type of angina. ADEFIN XL IS NOT USED TO RELIEVE SUDDEN ATTACKS OF ANGINA. ADEFIN XL belongs to a group of medicines called calcium channel blockers. Calcium channel blockers work by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. ADEFIN XL tablets are specially designed with a strong outer shell. This outer shell allows the medicine to be released slowly into the body over a longer period of time after it is taken. The outer shell is excreted or passed out in the faeces (or bowel motions), as it does not dissolve in the body. Therefore, it is normal to find a "tablet-like" object in the faeces. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY ADEFIN XL HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is only available with a doctor's prescription. BEFORE YOU TAKE ADEFIN XL _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE ADEFIN XL IF YOU ARE ALLERGIC TO: • medicines containing nifedipine (eg. Adalat OROS, Adefin) • medicines similar to nifedipine such as amlodipine (Norvasc), felodipine (Plendil, Felodur), lercanidipine (Zanidip), nimodipine (Nimotop) • any of Baca dokumen lengkapnya
ADEFIN ® XL _Nifedipine _ PRODUCT INFORMATION NAME OF THE MEDICINE Active ingredient: Nifedipine Chemical name: dimethyl 1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate Structural formula: Molecular formula: C 17 H 18 N 2 O 6 Molecular Weight: 346.3 CAS Registry No: 21829-25-4 DESCRIPTION Nifedipine is a yellow crystalline substance practically insoluble in water, and sparingly soluble in absolute ethanol. It is sensitive to light. ADEFIN XL tablets are a controlled release formulation containing nifedipine USP 30 mg or 60 mg. Besides the active ingredient, ADEFIN XL 30 mg and 60 mg tablets also contain the following inactive ingredients: polyethylene oxide, magnesium stearate, sodium chloride, hypromellose, iron oxide red (CI 77491), hydroxypropylcellulose, cellulose acetate, macrogol 3350, titanium dioxide and propylene glycol. ADEFIN XL tablets are similar in appearance to conventional tablets. Each tablet consists of a semipermeable membrane surrounding an osmotically active core. The core itself is divided into two layers: an "active" layer containing nifedipine, and a "push" layer containing pharmacologically inert but osmotically active components. As water from the gastrointestinal tract enters the tablet, pressure increases in the osmotic layer and "pushes" against the nifedipine layer, releasing nifedipine through a precision laser-drilled tablet orifice in the "active" layer. The coating of ADEFIN XL remains intact during the gastrointestinal passage and is eliminated in the faeces. ADEFIN XL – Product Information 2 PHARMACOLOGY Nifedipine is a calcium ion influx inhibitor (calcium Baca dokumen lengkapnya