Negara: Taiwan
Bahasa: China
Sumber: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)
METFORMIN
台灣默克股份有限公司 台北市內湖區堤頂大道2段89號6樓 (23526610)
A10BA02
膜衣錠
METFORMIN (6820400700) (equivalent to metformin base)(780mg)MG
塑膠瓶裝;;鋁箔盒裝
製 劑
須由醫師處方使用
MERCK SANTE S.A.S. – CENTRE DE MEYZIEU 10 AVENUE DE LATTRE DE TASSIGNY 69330 MEYZIEU – FRANCE FR
metformin
「成人及12歲(含)以上的兒童或青少年之第二型糖尿病患者。」說明:飲食控制及運動皆無法達到理想的血糖控制下,可選擇Glucophage作為其輔助療法。
註銷日期: 2017/04/12; 註銷理由: 自請註銷; 有效日期: 2017/07/06; 英文品名: Glucophage Film-coated tablets 1000mg
已註銷
2012-07-06
FILM-COATED TABLETS METFORMINHYDROCHLORIDE COMPOSITIONEach film-coated tablet of Glucophage 500 mg contains as active ingredient 500 mg metformin hydrochloride (equivalent to 390 mg metformin base). Baca dokumen lengkapnyaEach film-coated tablet of Glucophage 850 mg contains as active ingredient 850 mg metformin hydrochloride (equivalent to 663 mg metformin base) Each film-coated tablet of Glucophage 1000 mg contains as active ingredient 1000 mg metformin hydrochloride (equivalent to 780 mg metformin base). Excipients: Povidone K30, magnesium stearate and hypromellose Povidone K30, magnesium stearate, hypromellose, macrogol 400 and macrogol 8000 PROPERTIES PHARMACODYNAMICS Glucophage is an antidiabetic medicine that belongs to the group of biguanides. Metformin, the active ingredient in Glucophage, reduces hepatic glucose production, increases insulin sensitivity in muscles and delays intestinal glucose absorption. A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with Glucophage as first-line therapy after diet therapy. Glucophage is associated with either a stable body weight or modest weight loss. PHARMACOKINETICS Absorption: After an oral dose of metformin hydrochloride tablet, maximum plasma concentration (C max ) is reached in approximately 2.5 hours (t max ). Absolute bioavailability of a 500 mg or 850 mg metformin hydrochloride tablet is approximately 50-60% in healthy subjects. After an oral dose, the non-absorbed fraction recovered in faeces was 20-30%. After oral administration, metformin absorption is saturable and incomplete. It is assumed that the pharmacokinetics of metformin absorption is non-linear. At the recommended metformin doses and dosing schedules, steady state plasma concentrations are reached within 24 to 48 hours and are generally less than 1 microgram/ml. In controlled clinical trials, maximum metformin plasma levels (C max ) did no